Iamaroon Arissara, Raksakietisak Manee, Halilamien Pathom, Hongsawad Jitaporn, Boonsararuxsapong Kwankamol
Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Local Reg Anesth. 2010;3:21-6. doi: 10.2147/lra.s8600. Epub 2010 Mar 25.
Fracture of femur is a painful bone injury, worsened by any movement. This prospective study was performed to compare the analgesic effects of femoral nerve block (FNB) with intravenous (IV) fentanyl prior to positioning patients with fractured femur for spinal block.
Sixty-four ASA I-III patients aged 18-80 years undergoing surgery for femur fracture were randomized into two groups. Fifteen minutes before spinal block, the FNB group received nerve stimulator-assisted FNB with a mixture of 20 mL bupivacaine 0.5% and 10 mL normal saline 0.9%, and the fentanyl group received two doses of IV fentanyl 0.5 μg/kg with a five-minute interval between doses. Numeric rating pain scores were compared. During positioning, fentanyl in 0.5 μg/kg increments was given every five minutes until pain scores were ≤4.
There were no statistically significant differences between the groups according to pain scores, need for additional fentanyl, and satisfaction with positioning before spinal block.
We were unable to demonstrate a benefit of FNB over IV fentanyl for patient positioning before spinal block. However, FNB can provide postoperative pain relief, whereas side effects of fentanyl must be considered, and analgesic dosing should be titrated based on pain scores. A multimodal approach (FNB + IV fentanyl) may be a possible option.
股骨骨折是一种疼痛性骨损伤,任何活动都会使其加重。本前瞻性研究旨在比较在为股骨骨折患者进行脊髓阻滞定位前,股神经阻滞(FNB)与静脉注射(IV)芬太尼的镇痛效果。
64例年龄在18 - 80岁、接受股骨骨折手术的美国麻醉医师协会(ASA)I - III级患者被随机分为两组。在脊髓阻滞前15分钟,FNB组接受神经刺激器辅助的FNB,使用20 mL 0.5%布比卡因和10 mL 0.9%生理盐水的混合液,芬太尼组接受两剂静脉注射芬太尼,剂量为0.5 μg/kg,两剂之间间隔5分钟。比较数字评分法疼痛评分。在定位过程中,每5分钟以0.5 μg/kg的增量给予芬太尼,直至疼痛评分≤4。
根据疼痛评分、额外芬太尼的需求以及脊髓阻滞前对定位的满意度,两组之间无统计学显著差异。
我们未能证明在脊髓阻滞前为患者定位时,FNB比静脉注射芬太尼更具优势。然而,FNB可提供术后疼痛缓解,而芬太尼的副作用必须予以考虑,镇痛剂量应根据疼痛评分进行滴定。多模式方法(FNB + 静脉注射芬太尼)可能是一种选择。