肝脏药物清除率：以吲哚菁绿为模型化合物研究年龄的影响。
Hepatic drug clearance: the effect of age using indocyanine green as a model compound.
作者信息
Wynne H A, Goudevenos J, Rawlins M D, James O F, Adams P C, Woodhouse K W
机构信息
Geriatric Clinical Pharmacology Unit, University of Newcastle upon Tyne.
出版信息
Br J Clin Pharmacol. 1990 Oct;30(4):634-7. doi: 10.1111/j.1365-2125.1990.tb03826.x.
Abstract
The hepatic extraction ratio and clearance of indocyanine green (ICG) were determined and used to derive apparent liver blood flow in nine subjects between the ages of 22 and 83 years. There was no correlation between the hepatic extraction ratio of ICG and age (rs = -0.435, NS). There was a significant negative correlation between both ICG clearance and age (rs = -0.710, P less than 0.05) and apparent liver blood flow and age (rs = -0.750, P less than 0.05). These results validate the comparison of liver blood flow values derived from ICG clearance in humans over a wide age range and confirm that liver blood flow does fall with age.
摘要
测定了9名年龄在22岁至83岁之间受试者的肝脏对吲哚菁绿（ICG）的摄取率和清除率，并据此推算出肝脏的表观血流量。ICG的肝脏摄取率与年龄之间无相关性（rs = -0.435，无统计学意义）。ICG清除率与年龄（rs = -0.710，P < 0.05）以及肝脏表观血流量与年龄（rs = -0.750，P < 0.05）之间均存在显著的负相关。这些结果验证了在较宽年龄范围内通过ICG清除率得出的肝脏血流量值的可比性，并证实肝脏血流量确实会随年龄增长而下降。
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