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甲基胆蒽诱导的小鼠呼吸道鳞状细胞癌中内源性嗜异性逆转录病毒的表达

Expression of endogenous xenotropic retrovirus by methylcholanthrene-induced squamous cell carcinoma of the mouse respiratory tract.

作者信息

Ebenstein P, Kinder B, Bankole D O, Richards F F, Armstrong M Y

出版信息

J Exp Med. 1979 Dec 1;150(6):1567-70. doi: 10.1084/jem.150.6.1567.

Abstract

As a model for human lung cancer, squamous cell carcinomas were induced by 3-methylcholanthrene in mouse tracheas which had been explanted to a subcutaneous site. The tumors that developed were examined for both ecotropic and xenotropic infectious murine leukemia virus (MuLV). From all squamous carcinomas--six out of six--a xenotropic MuLV was isolated. From some of the fibrosarcomas that occurred incidentally in our induction system, ecotropic MuLV was isolated. However, in the fibrosarcomas, no xenotropic MuLV at all was found.

摘要

作为人类肺癌的模型,将3-甲基胆蒽注入移植到皮下部位的小鼠气管中,诱发鳞状细胞癌。对所形成的肿瘤进行嗜亲性和异嗜性感染性鼠白血病病毒(MuLV)检测。在所有鳞状细胞癌中(6例中的6例),均分离出异嗜性MuLV。在我们的诱导系统中偶然出现的一些纤维肉瘤中,分离出了嗜亲性MuLV。然而,在这些纤维肉瘤中,未发现任何异嗜性MuLV。

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