Departments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Curr Opin Chem Biol. 2012 Dec;16(5-6):595-601. doi: 10.1016/j.cbpa.2012.07.014. Epub 2012 Aug 23.
Hydrogen sulfide (H(2)S) has long been recognized as a toxic molecule in biological systems. However, emerging studies now link controlled fluxes of this reactive sulfur species to cellular regulation and signaling events akin to other small molecule messengers, such as nitric oxide, hydrogen peroxide, and carbon monoxide. Progress in the development of fluorescent small-molecule indicators with high selectivity for hydrogen sulfide offers a promising approach for studying its production, trafficking, and downstream physiological and/or pathological effects.
硫化氢(H(2)S)长期以来一直被认为是生物系统中的有毒分子。然而,新兴的研究现在将这种反应性硫物种的受控通量与细胞调节和信号事件联系起来,类似于其他小分子信使,如一氧化氮、过氧化氢和一氧化碳。具有高选择性的荧光小分子指示剂的发展为研究其产生、运输以及下游生理和/或病理作用提供了一种很有前途的方法。