Cavellani Camila Lourencini, Rocha Laura Penna, da Silva Rosa Simone Cristina, Oliveira Livia Ferreira, Faria Humberto Aparecido, Olegario Janainna Grazielle Pacheco, Correa Rosana Rosa Miranda, Teixeira Vicente de Paula Antunes
General Pathology Division, Triangulo Mineiro Federal University, Uberaba, Minas Gerais, Brazil.
Curr HIV Res. 2011 Dec 1;9(8):606-12. doi: 10.2174/157016211798998745.
Previous studies have shown that HIV infection is related to changes in the immune status of the mucosal surfaces. Such changes may also occur in the genital tract, since patients infected by HIV have the virus in their cervical secretions.
Fragments of the uterine cervix of 29 autopsied women were collected at a university hospital from 1985 to 2008, and were divided in groups with and without AIDS. Image J software was used to measure the cervical epithelium and to count the epithelial cellular layers. Langerhans cells (LCs) and IgG positive cells were respectively immunostained with anti-S100 and anti-IgG.
Women with AIDS, when compared with women without AIDS, had thinner cervical epithelium (103.32 vs 116.71 μm), lower number of cellular layers (10.41 vs 13.66 μm), lower mean cell diameter (10.09 vs 11.51 μm), less number of total LCs (11.19 vs 23.08 LCs/mm(2)), and higher percentage of IgG positive cells (22.64% vs 16.06%). All these results were significant.
AIDS causes alterations in the structure of the cervical epithelium and in its extracellular matrix, leading to alterations in the local and systemic immunity, and triggering signs and opportunistic infections in the uterine cervix in the course of the disease.
先前的研究表明，HIV感染与黏膜表面免疫状态的变化有关。此类变化也可能发生在生殖道，因为感染HIV的患者宫颈分泌物中存在该病毒。
1985年至2008年期间，在一家大学医院收集了29名女性尸检的子宫颈组织切片，并分为患艾滋病组和未患艾滋病组。使用Image J软件测量宫颈上皮厚度并计算上皮细胞层数。分别用抗S100和抗IgG对朗格汉斯细胞（LCs）和IgG阳性细胞进行免疫染色。
与未患艾滋病的女性相比，患艾滋病的女性宫颈上皮更薄（103.32对116.71μm），细胞层数更少（10.41对13.66μm），平均细胞直径更小（10.09对11.51μm），总LCs数量更少（11.19对23.08个LCs/mm²），IgG阳性细胞百分比更高（22.64%对16.06%）。所有这些结果均具有显著性。
艾滋病会导致宫颈上皮及其细胞外基质结构的改变，从而引起局部和全身免疫的改变，并在疾病过程中引发子宫颈的体征和机会性感染。
