Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Eur J Obstet Gynecol Reprod Biol. 2012 Dec;165(2):215-8. doi: 10.1016/j.ejogrb.2012.08.012. Epub 2012 Aug 22.
The objective of the study was to measure the copeptin levels in maternal serum and umbilical cord serum at cesarean section and vaginal delivery in normotensive pregnancy and pre-eclamptic women.
This was a prospective study at Mansoura University Hospital, Egypt. Ninety cases were included. They were divided into six groups: (1) normal pregnancy near term, as a control group, (2) primiparas who had vaginal delivery, (3) primiparas who had vaginal delivery and mild preeclampsia, (4) elective repeat cesarean section, (5) intrapartum cesarean section for indications other than fetal distress, and (6) intrapartum cesarean section for fetal distress. Serum copeptin concentrations were quantified with an enzyme-linked immunosorbent assay (ELISA). Mean, standard deviation, and paired t-test were used to test for significant change in quantitative data.
The vaginal delivery groups had higher levels of maternal serum copeptin than the elective cesarean section group (P<0.01). Higher maternal serum copeptin levels were found in cases with pre-eclampsia as compared with the normotensive cases. The maternal copeptin levels during intrapartum cesarean section were higher than that during elective repeat cesarean section. There was a significant correlation between maternal copeptin levels and the duration of the first stage. In the presence of fetal distress, umbilical cord serum copeptin levels were significantly higher than other groups.
Vaginal delivery can be very painful and stressful, and is accompanied by a marked increase of maternal serum copeptin. Increased maternal levels of serum copeptin were found in cases with pre-eclampsia as compared with the normotensive cases, and it may be helpful in assessing the disease. Intrauterine fetal distress is a strong stimulus to the release of copeptin into the fetal circulation.
本研究旨在测量正常妊娠和子痫前期孕妇剖宫产和阴道分娩时母血清和脐血清中的 copeptin 水平。
这是埃及曼苏拉大学医院的一项前瞻性研究。纳入 90 例病例。将其分为六组：（1）足月正常妊娠作为对照组，（2）阴道分娩初产妇，（3）阴道分娩且轻度子痫前期初产妇，（4）择期剖宫产，（5）因非胎儿窘迫行剖宫产，（6）因胎儿窘迫行剖宫产。采用酶联免疫吸附试验（ELISA）定量检测血清 copeptin 浓度。采用均值、标准差和配对 t 检验来检验定量数据的显著变化。
阴道分娩组母血清 copeptin 水平高于择期剖宫产组（P<0.01）。与正常血压病例相比，子痫前期病例的母血清 copeptin 水平更高。与择期重复剖宫产相比，产时剖宫产时母血清 copeptin 水平更高。母血清 copeptin 水平与第一产程持续时间呈显著正相关。在存在胎儿窘迫的情况下，脐血清 copeptin 水平明显高于其他组。
阴道分娩可能非常痛苦和有压力，并伴有母血清 copeptin 水平的显著增加。与正常血压病例相比，子痫前期病例的母血清 copeptin 水平升高，可能有助于评估疾病。胎儿宫内窘迫是胎儿循环中 copeptin 释放的强烈刺激因素。
