Vasant Rupal A, Narasimhacharya A V R L
Department of Biosciences, Laboratory for Animal Sciences, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India.
J Pharm Bioallied Sci. 2012 Jul;4(3):250-4. doi: 10.4103/0975-7406.99067.
Purpose of the study was to examine the antihyperglycemic and hepato-renal protective effects of Emblica officinalis (Eo) fruit as a food supplement in fluoride induced toxicity. Eo fruit powder was incorporated into the diet (2.5, 5 and 10 gm %) of fluoride exposed animals for a duration of 30 days. Fluoride exposure caused significant elevation in plasma glucose, serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), acid phosphatase (ACP), alkaline phosphatase (ALP) activities, hepatic glucose-6-phosphatase (G-6-Pase) and decreased hepatic glycogen content, hexokinase activity and antioxidant profiles (hepatic and renal). An inclusion of Eo fruit powder significantly reduced plasma glucose levels, SGOT, SGPT, ACP and ALP activities, hepatic G-6-Pase activity and increased hepatic glycogen content and hexokinase activity. Hepatic and renal antioxidant status of fluoride exposed animals improved upon feeding Eo fruit powder. We, therefore, conclude that E. officinalis fruit could be useful in regulating hyperglycemia and enhances antioxidant status of fluoride exposed animals.
本研究的目的是考察余甘子果实作为一种食品补充剂在氟诱导毒性中对降血糖及肝肾的保护作用。将余甘子果粉添加到暴露于氟的动物饮食中（2.5%、5%和10%克），持续30天。氟暴露导致血浆葡萄糖、血清谷氨酸草酰乙酸转氨酶（SGOT）、血清谷氨酸丙酮酸转氨酶（SGPT）、酸性磷酸酶（ACP）、碱性磷酸酶（ALP）活性显著升高，肝葡萄糖-6-磷酸酶（G-6-Pase）升高，肝糖原含量、己糖激酶活性及抗氧化指标（肝脏和肾脏）降低。添加余甘子果粉可显著降低血浆葡萄糖水平、SGOT、SGPT、ACP和ALP活性、肝G-6-Pase活性，并增加肝糖原含量和己糖激酶活性。给暴露于氟的动物喂食余甘子果粉后，其肝脏和肾脏的抗氧化状态得到改善。因此，我们得出结论，余甘子果实可能有助于调节高血糖，并增强暴露于氟的动物的抗氧化状态。
