Laboratory for Animal Sciences, Department of Biosciences, Sardar Patel Maidan, Sardar Patel University, Vadtal Road, Satellite Campus, Vallabh Vidyanagar, Postbox 39, 388 120 Gujarat, India.
J Food Sci Technol. 2013 Jun;50(3):528-34. doi: 10.1007/s13197-011-0367-3. Epub 2011 May 5.
Fluorosis is a major health problem in many parts of the world. The present work focuses on investigating the utility of nutrient and antioxidant rich grains- ragi, jowar, bajra, maize in formulation of basal, high carbohydrate low protein and low carbohydrate high protein diets in mitigating fluoride toxicity. Exposure to fluoride through drinking water not only significantly increased plasma glucose and lipid profiles, but also elevated both hepatic and renal lipid peroxidation, hepatic lipid profiles and G-6-Pase activity with a reduction in plasma HDL-C, hepatic glycogen content, hexokinase activity and antioxidant status. Even though basal and high carbohydrate diets did not significantly alter plasma glucose, lipid profiles in fluoride administered animals, protein enriched multigrain diet significantly decreased plasma glucose and lipid levels. However, the multigrain basal and high carbohydrate diets influenced the hepatic glycogen, lipid profiles, hexokinase and G-6-Pase activities, hepatic and renal lipid peroxidation and antioxidant status though not as significantly as that of multigrain diet enriched with protein. Thus the results of the present study indicate that both a multigrain diet rich in nutrients and antioxidants, and fortified with protein is useful in mitigating the fluoride toxicity.
氟中毒是世界上许多地区的一个主要健康问题。本研究重点探讨了在制定基础、高碳水化合物低蛋白和低碳水化合物高蛋白饮食中，使用富含营养和抗氧化剂的谷物——珍珠粟、高粱、黍、玉米的效用，以减轻氟化物毒性。通过饮用水接触氟化物不仅显著增加了血浆葡萄糖和脂质谱，还增加了肝和肾的脂质过氧化、肝脂质谱和 G-6-Pase 活性，同时降低了血浆高密度脂蛋白胆固醇、肝糖原含量、己糖激酶活性和抗氧化状态。尽管基础和高碳水化合物饮食并没有显著改变氟化物处理动物的血浆葡萄糖和脂质谱，但富含蛋白质的多种谷物饮食显著降低了血浆葡萄糖和脂质水平。然而，多种谷物基础和高碳水化合物饮食虽然没有像富含蛋白质的多种谷物饮食那样显著影响肝糖原、脂质谱、己糖激酶和 G-6-Pase 活性、肝和肾的脂质过氧化和抗氧化状态，但还是有一定影响。因此，本研究结果表明，富含营养和抗氧化剂的多种谷物饮食，以及富含蛋白质的强化饮食，均有助于减轻氟化物毒性。
