Burbelo Peter D, Kovacs Joseph A, Wagner Jason, Bayat Ahmad, Rhodes Craig S, De Souza Yvonne, Greenspan John S, Iadarola Michael J
Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, Bethesda, MD 20893, USA.
AIDS Res Treat. 2012;2012:634523. doi: 10.1155/2012/634523. Epub 2012 Aug 8.
Although HIV-positive patients are at higher risk for developing a variety of infection-related cancers, the prevalence of infections with the seven known cancer-associated viruses has not been studied. Luciferase immunoprecipitation systems were used to evaluate antiviral antibodies in four 23-person groups: healthy blood donors and HIV-infected patients with oral hairy leukoplakia (OLP), Kaposi's sarcoma (KS), or non-Hodgkin lymphoma (NHL). Antibody profiling revealed that all HIV-positive individuals were strongly seropositive for anti-gp41 and antireverse transcriptase antibodies. However, anti-p24 HIV antibody levels were highly variable and some OLP and KS patients demonstrated weak or negative responses. Profiling two EBV antigens revealed no statistical difference in antibody levels among the three HIV-infected groups. A high frequency of KSHV infection was detected in HIV patients including 100% of KS, 78% of OLP, and 57% of NHL patients. Most HIV-infected subjects (84%) showed anti-HBV core antibodies, but only a few showed antibodies against HCV. MCV seropositivity was also common (94%) in the HIV-infected individuals and KS patients showed statistically higher antibody levels compared to the OLP and NHL patients. Overall, 68% of the HIV-infected patients showed seropositivity with at least four cancer-associated viruses. Antibody profiles against these and other infectious agents could be useful for enhancing the clinical management of HIV patients.
尽管HIV阳性患者患各种感染相关癌症的风险更高，但尚未对七种已知的癌症相关病毒的感染率进行研究。使用荧光素酶免疫沉淀系统评估了四个23人组中的抗病毒抗体：健康献血者以及患有口腔毛状白斑（OLP）、卡波西肉瘤（KS）或非霍奇金淋巴瘤（NHL）的HIV感染患者。抗体分析显示，所有HIV阳性个体的抗gp41和抗逆转录酶抗体均呈强血清阳性。然而，抗p24 HIV抗体水平高度可变，一些OLP和KS患者表现出弱阳性或阴性反应。对两种EBV抗原进行分析发现，三个HIV感染组之间的抗体水平无统计学差异。在HIV患者中检测到KSHV感染的频率很高，包括100%的KS患者、78%的OLP患者和57%的NHL患者。大多数HIV感染受试者（84%）显示抗HBV核心抗体，但只有少数人显示抗HCV抗体。MCV血清阳性在HIV感染者中也很常见（94%），与OLP和NHL患者相比，KS患者的抗体水平在统计学上更高。总体而言，68%的HIV感染患者至少对四种癌症相关病毒呈血清阳性。针对这些和其他感染因子的抗体谱可能有助于加强HIV患者的临床管理。
