Ouologuem Dinkorma T, Djimdé Abdoulaye A, Diallo Nouhoum, Doumbo Ogobara K, Roos David S
Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Science, Techniques and Technologies of Bamako, Mali.
J Parasitol. 2013 Apr;99(2):371-4. doi: 10.1645/GE-3239.1. Epub 2012 Aug 27.
The protozoan parasite Toxoplasma gondii is globally distributed, with considerable local variation in prevalence based on behavioral and environmental factors. To assess prevalence and estimate risk in Mali, we conducted a survey of 760 serum samples previously collected for malaria studies. A modified agglutination test detected antibodies in ∼27% of the adult population, with no significant differences between men and women, or between urban and rural study sites. In the village of Kolle, seroprevalence rose from 0% in infants (<1 yr, but after weaning of maternal immunoglobulin G) to 0.8% (1-5 yr), 2.7% (6-10), 11.3% (11-15), and 26.8% (>15); differences between the <10-, 11-15-, and >15-yr age groups were highly significant (P ≤ 0.01). We also observed an increase in anti- T. gondii antibody titers with age. Modeling the observed age distribution suggests a seroconversion rate of ∼1%/yr, indicating that congenital toxoplasmosis may be an under-appreciated public health concern in Mali.
原生动物寄生虫刚地弓形虫在全球范围内均有分布，其感染率因行为和环境因素在局部地区存在显著差异。为评估马里的感染率并估计风险，我们对之前为疟疾研究采集的760份血清样本进行了调查。改良凝集试验在约27%的成年人群中检测到抗体，男性与女性之间、城市与农村研究地点之间均无显著差异。在科勒村，血清阳性率从婴儿（<1岁，但已断奶，母体免疫球蛋白G消失后）的0%升至0.8%（1 - 5岁）、2.7%（6 - 10岁）、11.3%（11 - 15岁）和26.8%（>15岁）；<10岁、11 - 15岁和>15岁年龄组之间的差异极为显著（P≤0.01）。我们还观察到抗刚地弓形虫抗体滴度随年龄增长而升高。对观察到的年龄分布进行建模表明血清转化率约为1%/年，这表明先天性弓形虫病可能是马里一个未得到充分重视的公共卫生问题。
