Mohr Sharif B, Gorham Edward D, Alcaraz John E, Kane Christopher I, Macera Caroline A, Parsons J Kellogg, Wingard Deborah L, Garland Cedric F
Dermatoendocrinol. 2012 Apr 1;4(2):152-7. doi: 10.4161/derm.20449.
A wide range of epidemiologic and laboratory studies combined provide compelling evidence of a protective role of vitamin D on risk of breast cancer. This review evaluates the scientific evidence for such a role in the context of the A.B. Hill criteria for causality, in order to assess the presence of a causal, inverse relationship, between vitamin D status and breast cancer risk. After evaluation of this evidence in the context of Hill's criteria, it was found that the criteria for a causal relationship were largely satisfied. Studies in human populations and the laboratory have consistently demonstrated that vitamin D plays an important role in the prevention of breast cancer. Vitamin D supplementation is an urgently needed, low cost, effective, and safe intervention strategy for breast cancer prevention that should be implemented without delay. In the meantime, randomized controlled trials of high doses of vitamin D(3) for prevention of breast cancer should be undertaken to provide the necessary evidence to guide national health policy.
大量的流行病学和实验室研究综合起来，提供了令人信服的证据，证明维生素D对乳腺癌风险具有保护作用。本综述在A.B.希尔因果关系标准的背景下评估了支持这一作用的科学证据，以评估维生素D状态与乳腺癌风险之间是否存在因果反比关系。在希尔标准的背景下对这一证据进行评估后发现，因果关系的标准在很大程度上得到了满足。人群研究和实验室研究一致表明，维生素D在预防乳腺癌中起着重要作用。补充维生素D是一种迫切需要的、低成本、有效且安全的乳腺癌预防干预策略，应立即实施。与此同时，应开展高剂量维生素D(3)预防乳腺癌的随机对照试验，以提供必要的证据来指导国家卫生政策。
