Bobiński Rafał, Mikulska Monika, Mojska Hanna, Simon Michał
Department of Health Science, University of Bielsko-Biala , Bielsko-Biala, Poland.
J Matern Fetal Neonatal Med. 2013 Jan;26(1):96-102. doi: 10.3109/14767058.2012.722717. Epub 2012 Sep 25.
The aim of this study was to determine and compare the fatty acid (FA) profile of maternal blood and cord blood of children born at term (group A); those born prematurely (group B); and children born with hypotrophic features (group C).
The study consisted of 109 women. FA composition was determined by gas chromatography-mass spectrometry.
Twenty-two FAs were identified in the maternal blood and 33 FAs were identified in the cord blood. Significant differences in the levels of C18:3n-6 and C20:5n-3 were noted when comparing the FA composition of maternal blood samples from the three different groups (A, B, and C). Seven statistical differences were detected in the cord blood. They concerned C12:0, C18:0, C18:1c, C18:3n-6, C20:0, C20:3n-6, and C20:4n-6.
Our research has shown that the FA profile of both the maternal blood and the cord blood undergoes changes in response to pregnancy duration and the presence of reduced fetal growth. Statistical differences between groups B and C compared with group A, show that the placental-fetal transport of FA in group B and C infants may differ from that of group A children.
本研究旨在测定并比较足月出生儿童（A组）、早产儿童（B组）和低体重儿（C组）的母亲血液和脐带血中的脂肪酸（FA）谱。
该研究纳入了109名女性。通过气相色谱 - 质谱法测定脂肪酸组成。
在母亲血液中鉴定出22种脂肪酸，在脐带血中鉴定出33种脂肪酸。比较来自三个不同组（A、B和C）的母亲血液样本的脂肪酸组成时，发现C18:3n - 6和C20:5n - 3水平存在显著差异。在脐带血中检测到7个统计学差异。它们涉及C12:0、C18:0、C18:1c、C18:3n - 6、C20:0、C20:3n - 6和C20:4n - 6。
我们的研究表明，母亲血液和脐带血中的脂肪酸谱会因孕期时长和胎儿生长受限而发生变化。与A组相比，B组和C组之间的统计学差异表明，B组和C组婴儿的脂肪酸胎盘 - 胎儿转运可能与A组儿童不同。
