Hsp90-beta 和膜联蛋白 A1 的上调与肺癌患者的不良生存和淋巴转移相关。
Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients.
机构信息
Department of Respiratory Medicine, Second Affiliated Hospital, Xi'an Jiaotong University, 157, Xi 5 Road, Xi'an 710004, People's Republic of China.
出版信息
J Exp Clin Cancer Res. 2012 Aug 28;31(1):70. doi: 10.1186/1756-9966-31-70.
BACKGROUND
Hsp90-beta and annexin A1 were investigated as prognostic factors because of their apparent association with tumorigenesis. However, the effect of Hsp90-beta and annexin A1 in lung cancer remains poorly understood. The expressions of Hsp90-beta and annexin A1 in lung cancer and normal lung specimens were examined, and the relationships with respect to the clinico-pathological features and patient survival in lung cancer were analyzed.
METHODS
The expression levels of Hsp90-beta and annexin A1 were examined using immunohistochemistry, in-situ hybridization, and Western blot.
RESULTS
Lung cancer tissues exhibited higher expression levels of Hsp90-beta and annexin A1 than the normal tissues (p < 0.05), and the expression levels of the markers were significantly associated with the pathological grade and lymphatic invasion of lung cancer (p < 0.05). Moreover, the upregulation of Hsp90-beta and annexin A1 correlated with decreased survival (p < 0.05).
CONCLUSION
The upregulation of Hsp90-beta and annexin A1 were associated with poor post-surgical survival time and lymphatic metastasis of lung cancer patients. Moreover, the high expression of the markers was an independent predictor of poor outcomes.
背景
Hsp90-β 和膜联蛋白 A1 被认为是与肿瘤发生明显相关的预后因素。然而，Hsp90-β 和膜联蛋白 A1 在肺癌中的作用仍知之甚少。本研究检测了肺癌及正常肺组织中 Hsp90-β 和膜联蛋白 A1 的表达，并分析了其与肺癌临床病理特征及患者生存的关系。
方法
采用免疫组织化学、原位杂交和 Western blot 检测 Hsp90-β 和膜联蛋白 A1 的表达水平。
结果
肺癌组织中 Hsp90-β 和膜联蛋白 A1 的表达水平高于正常组织（p<0.05），且标志物的表达水平与肺癌的病理分级和淋巴浸润显著相关（p<0.05）。此外，Hsp90-β 和膜联蛋白 A1 的上调与生存时间缩短相关（p<0.05）。
结论
Hsp90-β 和膜联蛋白 A1 的上调与肺癌患者术后生存时间和淋巴转移不良相关。此外，高表达这些标志物是不良预后的独立预测因子。
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