Department of Health Policy and Management, Boston University School of Public Health, Boston, MA 02118, USA.
J Trauma Acute Care Surg. 2012 Sep;73(3 Suppl 2):S179-88. doi: 10.1097/TA.0b013e318265c552.
The Multi-Center Benchmarking Study (MCBS) is an innovative program giving a new paradigm for monitoring health outcomes in children and adolescents with burn injuries.
This article presents the methodologies for conducting a multicenter long-term cohort study of 1,140 children and adolescents with small to large burn injuries followed from the acute burn discharge at four burn centers for up to 4 years. The components for this project include a broad and rich range of patient-centered health assessments tailored to children with burn injury, an infrastructure for obtaining relevant clinical data, and patient-centered questionnaire data based on validated Shriners Hospitals for Children/American Burn Association Burn Outcomes Questionnaire (BOQ) and Short-Form Psychosocial Questionnaire, aged 0 years to 18 years. Recovery curves are described for analysis of complex data with repeated measures that are based on mixed models and generalized estimating equations, with adjustments for clinical characteristics.
Accrual rates are as high as 93%, and follow-up rates of completion are 65%. Recovery curves for selected BOQ domains (upper extremity function, patient compliance, and parental concern) are presented for those children and adolescents aged 5 years to 18 years using the rich cohort of data from the MCBS. Results suggest that the BOQ is sensitive and responsive to capturing differences in the rate and levels of change over time.
The methods implemented in the MCBS are a useful model for conducting large multicenter studies to track the clinical and quality of life of children with burn injuries.
多中心基准研究（MCBS）是一个创新性项目，为监测烧伤患儿的健康结果提供了新的范例。
本文介绍了对四家烧伤中心的 1140 名大小面积烧伤儿童和青少年进行为期 4 年的多中心长期队列研究的方法。该项目的组成部分包括广泛而丰富的以烧伤患儿为中心的健康评估，以及获取相关临床数据的基础设施，以及基于 Shriners 儿童医院/美国烧伤协会烧伤结局问卷（BOQ）和简短形式心理社会问卷的患者为中心的问卷数据，年龄为 0 至 18 岁。基于混合模型和广义估计方程，对重复测量的复杂数据进行描述性分析，调整了临床特征。
入组率高达 93%，完成随访率为 65%。使用 MCBS 的丰富队列数据，为年龄在 5 至 18 岁的儿童和青少年展示了选定 BOQ 领域（上肢功能、患者依从性和父母关注）的恢复曲线。结果表明，BOQ 能够敏感和准确地捕捉到随时间变化的速率和水平的差异。
MCBS 中实施的方法是进行大型多中心研究的有效模型，可用于跟踪烧伤儿童的临床和生活质量。
