Department of Neuroscience, Unit of Functional Pharmacology, Uppsala University, Uppsala, Sweden.
Obes Rev. 2012 Dec;13(12):1096-109. doi: 10.1111/j.1467-789X.2012.01025.x. Epub 2012 Aug 29.
In 2007, the first common genetic variants were identified, which undoubtedly affect our susceptibility to obesity. These variants are located in the fat mass and obesity-associated gene FTO. Since then, over 50 loci for common obesity have been identified. As the research on these loci is still at an early stage, there is a great need to review, for clarification purposes, the current research on FTO, as this is likely to influence future studies. Based on the current knowledge, FTO seems to be directly involved in the regulation of energy intake, but there is an urgent need for the identification of regulatory polymorphisms. Thus, herein, we discuss current knowledge and highlight putative functional regions in FTO based on published data and computer-based analysis.
2007 年，首次确定了一些常见的遗传变异，这些变异无疑会影响我们肥胖的易感性。这些变异位于脂肪量和肥胖相关基因 FTO 中。此后，已确定了 50 多个常见肥胖相关基因座。由于对这些基因座的研究仍处于早期阶段，因此非常有必要对 FTO 的当前研究进行综述，以澄清问题，因为这可能会影响未来的研究。基于目前的知识，FTO 似乎直接参与了能量摄入的调节，但迫切需要确定调节多态性。因此，本文根据已发表的数据和基于计算机的分析，讨论了当前的知识，并强调了 FTO 中的假定功能区域。
