Eshchenko V A
Patol Fiziol Eksp Ter. 1990 Nov-Dec(6):42-4.
The acidotropic effect of chelates on insulocytes was demonstrated in experiments on dogs, cats, rabbits, rats, golden hamsters, and mice. On penetrating the cells these agents react with zinc and accumulate as complexes in the lysosome-segregation apparatus. The extent of damages occurring in the insulocytes in this case is determined by the amount of zinc bound by these agents.
螯合物对胰岛细胞的亲酸性作用已在狗、猫、兔、大鼠、金黄地鼠和小鼠的实验中得到证实。这些物质穿透细胞后，会与锌发生反应，并以复合物的形式在溶酶体分离装置中积累。在这种情况下，胰岛细胞发生损伤的程度取决于这些物质结合锌的量。
