从链霉菌 YIM 63342 中分离得到的新巨型倍半萜糖苷和生物碱。

New megastigmane glycoside and alkaloids from Streptomyces sp. YIM 63342.

机构信息

Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.

出版信息

Nat Prod Res. 2013;27(13):1191-6. doi: 10.1080/14786419.2012.718776. Epub 2012 Aug 30.

DOI:10.1080/14786419.2012.718776

PMID:22934740

Abstract

New sesquiterpene glycoside, cyclodipeptide and piperidine derivative were isolated from Streptomyces sp. YIM 63342. On the basis of spectral data, their structures were determined as 3R, 5R, 6S, 7E, 9R-megastigman-7-en-3,5,6,9-tetrol-9-O-β-D-apiofuranosyl-(1→ 2)-β-D-glucopyranoside (1), cyclo (L-Pro-L-OMet) (2) and (R)-(E, E)-2-(l,3-pentadienyl) piperidine (3), together with three known compounds as N-acetyltyramine (4), lycoperodine-1 (5), cyclo(L-Pro-L-Tyr)(6).

摘要

从链霉菌属 YIM 63342 中分离得到新的倍半萜糖苷、环二肽和哌啶衍生物。根据光谱数据，它们的结构被确定为 3R, 5R, 6S, 7E, 9R- 巨型二烯-7-烯-3,5,6,9-四醇-9-O-β-D-阿洛呋喃糖基-(1→2)-β-D-吡喃葡萄糖苷 (1)、环 (L-Pro-L-OMet) (2) 和 (R)-(E, E)-2-(1,3-戊二烯基)哌啶 (3)，以及三种已知化合物 N-乙酰酪胺 (4)、麦角酰二乙胺-1 (5)、环 (L-Pro-L-Tyr)(6)。