ICF International at FDA National Center for Toxicological Research, Jefferson, AR 72079, USA.
Drug Discov Today. 2013 Feb;18(3-4):110-5. doi: 10.1016/j.drudis.2012.08.005. Epub 2012 Aug 28.
Drug repositioning, exemplified by sildenafil and thalidomide, is a promising way to explore alternative indications for existing drugs. Recent research has shown that bioinformatics-based approaches have the potential to offer systematic insights into the complex relationships among drugs, targets and diseases necessary for successful repositioning. In this article, we propose the key bioinformatics steps essential for discovering valuable repositioning methods. The proposed steps (repurposing with a purpose, repurposing with a strategy and repurposing with confidence) are aimed at providing a repurposing pipeline, with particular focus on the proposed Drugs of New Indications (DNI) database, which can be used alongside currently available resources to improve in silico drug repositioning.
药物重定位，以西地那非和沙利度胺为例，是探索现有药物新适应症的一种很有前途的方法。最近的研究表明，基于生物信息学的方法有可能为成功的药物重定位提供系统的见解，了解药物、靶点和疾病之间复杂的关系。在本文中，我们提出了发现有价值的药物重定位方法所必需的关键生物信息学步骤。提出的步骤（有目的的重新定位、有策略的重新定位和有信心的重新定位）旨在提供一种重新定位的管道，特别关注提议的新药适应症（DNI）数据库，该数据库可以与现有的资源一起使用，以提高计算机药物重新定位的效果。
