J Neuroimmune Pharmacol. 2012 Dec;7(4):722-4. doi: 10.1007/s11481-012-9398-4. Epub 2012 Aug 31.
Many of the receptors which are responsible for the responses to the common drugs of abuse belong to the G protein-coupled receptor (GPCR) family. In this special issue of the Journal of Neuroimmune Pharmacology a collection of papers is presented which deals with signaling events that are important for the function of these receptors. Because these receptors are expressed by both neuronal and immune cells, and because these receptors play a complex role in regulating function in both the nervous and immune systems, a more complete understanding of the regulation of expression of these receptors is essential. Moreover, once these receptors are expressed and activated, a complex series of signaling events are initiated that can have substantial significance. We have only a limited understanding of these signaling events, but with more complete information, we may be able to control the undesirable and/or desirable consequences of receptor activation by drugs of abuse.
许多负责对常见滥用药物产生反应的受体属于 G 蛋白偶联受体 (GPCR) 家族。在本期《神经免疫药理学杂志》特刊中，发表了一系列论文，涉及对这些受体功能很重要的信号事件。由于这些受体既存在于神经元细胞也存在于免疫细胞中，并且由于这些受体在调节神经系统和免疫系统的功能方面发挥着复杂的作用，因此对这些受体表达的调控有一个更全面的理解是至关重要的。此外，一旦这些受体被表达和激活，就会启动一系列复杂的信号事件，这些信号事件可能具有重要意义。我们对这些信号事件的了解是有限的，但如果我们获得更完整的信息，也许就能够控制滥用药物引起的受体激活的不良和/或良好后果。
