Atkinson J C, Yeh C, Oppenheim F G, Bermudez D, Baum B J, Fox P C
Clinical Investigations and Patient Care Branch, National Institute of Dental Research, Bethesda, Maryland 20892.
J Acquir Immune Defic Syndr (1988). 1990;3(1):41-8.
Thirty-seven HIV-1-positive patients contributed salivary samples from individual major salivary glands. Nineteen patients were unmedicated and asymptomatic, and 18 patients had developed signs of AIDS. Salivas from 15 healthy males served as controls. Levels of four salivary antimicrobial proteins (lactoferrin, lysozyme, secretory IgA, and histatins) were determined, as well as total fluid output of the major salivary glands. Concentrations of all four salivary antimicrobial proteins were found to be increased in the stimulated submandibular/sublingual saliva of all HIV-1-positive patients as well as the subset of unmediated HIV-1-positive patients. Those patients with evidence of oral candidiasis had the highest concentrations of lysozyme and histatins, potent antifungal proteins, in their saliva. Although the etiology of these protein increases is still unknown, these results further document salivary changes following HIV-1 infection.
37名HIV-1阳性患者提供了来自各个主要唾液腺的唾液样本。19名患者未接受药物治疗且无症状，18名患者已出现艾滋病症状。15名健康男性的唾液用作对照。测定了四种唾液抗菌蛋白（乳铁蛋白、溶菌酶、分泌型IgA和组蛋白）的水平以及主要唾液腺的总液体分泌量。发现所有HIV-1阳性患者以及未接受治疗的HIV-1阳性患者亚组的刺激性颌下/舌下唾液中，所有四种唾液抗菌蛋白的浓度均升高。有口腔念珠菌病证据的患者唾液中溶菌酶和组蛋白（强效抗真菌蛋白）的浓度最高。尽管这些蛋白质增加的病因尚不清楚，但这些结果进一步证明了HIV-1感染后唾液的变化。
