Department of Anesthesiology and Pain Treatment, Maastricht University Medical Centre, Maastricht, The Netherlands.
Clin Appl Thromb Hemost. 2012 Nov;18(6):561-8. doi: 10.1177/1076029612458147. Epub 2012 Aug 30.
After the first description of platelets more than a century ago, the knowledge about their origin and function grew continuously. The development of the impedance method as a completely automated assay allowed integrating mean platelet volume (MPV) measurement as a routine parameter of the complete blood count. This enabled us to focus more on the association of platelet function and size. Since then, many authors described MPV as a marker of platelet reactivity and risk factor for cardiovascular diseases. Hence, the preanalytical variability of this parameter is known from its introduction as standard laboratory value. Unfortunately no preanalytical standards have been implemented. This review shows the high variability in the literature with MPV as a risk factor for cardiovascular disease. After a brief description of the biology of platelets, we provide an in-depth survey of the measurement methods and their drawbacks. Finally, we propose a possible approach to standardization.
一个多世纪前首次描述血小板后，人们对其起源和功能的认识不断增长。阻抗法的发展作为一种完全自动化的检测方法，允许将平均血小板体积 (MPV) 测量作为全血细胞计数的常规参数进行整合。这使我们能够更加关注血小板功能和大小之间的关联。从那时起，许多作者将 MPV 描述为血小板反应性的标志物和心血管疾病的危险因素。因此，自从将其作为标准实验室值引入以来，人们就已经了解到该参数的分析前变异性。遗憾的是，目前还没有分析前标准。本综述展示了文献中作为心血管疾病危险因素的 MPV 的高度变异性。在简要描述血小板的生物学特性后，我们深入调查了测量方法及其缺点。最后，我们提出了一种可能的标准化方法。
