Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
BMC Geriatr. 2012 Sep 2;12:49. doi: 10.1186/1471-2318-12-49.
Numerous emerging data from research on osteoporosis among Asians found differences from Caucasians. Therefore, the aim of this study was to determine the prevalence of vitamin D insufficiency and osteoporosis in elderly participants from two nursing homes in Thailand, a country located near the equator.
The subjects of this cross-sectional study comprised 93 elderly Thai women who were living in institutional long-term nursing homes for the aged. Demographic data, daily food and calcium intake, physical activity, and sunlight exposure were measured. Lumbar spine and femoral neck bone mineral density (BMD) and biochemical levels including serum 25 hydroxyvitamin D [25(OH)D] and bone turnover markers were assessed. Vitamin D insufficiency was defined as 25(OH)D level < 70 nmol/l.
The mean age of subjects was 75.2 ± 6.0 (SD) years. Dietary calcium intake was low (322 ± 158 mg/day) The mean 25(OH)D level was 64.3 ± 14.9 nmol/L and the prevalence of vitamin D insufficiency was 38.7% (95% CI: 28.8%, 49.4%). There was no correlation between serum 25(OH)D concentrations and age (r = -.11, p = 0.3). The mean BMD of lumbar spine and femoral neck were 0.92 ± 0.19 and 0.65 ± 0.10 g/cm2, respectively. Nearly a half of the subjects had osteopenia (44.1%, 95% CI: 33.8%, 54.8%) and osteoporosis (47.3%, 95% CI: 36.9%, 57.9%). Circulating C-terminal telopeptide of type I collagen (CTx) level correlated significantly with both lumbar spine (r = -0.26, p = 0.01) and femoral neck BMD (r = -0.25, p = 0.02).
More than one-third of Thai elderly women residing in nursing homes had vitamin D insufficiency. Almost all nursing home residents had osteoporosis and/or osteopenia.
许多亚洲人骨质疏松症的研究结果显示出与高加索人不同的结果。因此，本研究旨在确定泰国两个养老院老年参与者维生素 D 不足和骨质疏松症的患病率，泰国位于赤道附近。
本横断面研究的对象为 93 名居住在长期养老院的泰国老年女性。测量了人口统计学数据、日常饮食和钙摄入量、身体活动和阳光照射情况。评估了腰椎和股骨颈骨矿物质密度（BMD）和包括血清 25 羟基维生素 D [25(OH)D]和骨转换标志物在内的生化水平。维生素 D 不足定义为 25(OH)D 水平<70nmol/L。
受试者的平均年龄为 75.2±6.0（SD）岁。饮食中钙的摄入量较低（322±158mg/天）。平均 25(OH)D 水平为 64.3±14.9nmol/L，维生素 D 不足的患病率为 38.7%（95%CI：28.8%，49.4%）。血清 25(OH)D 浓度与年龄无相关性（r=-0.11，p=0.3）。腰椎和股骨颈的平均 BMD 分别为 0.92±0.19 和 0.65±0.10g/cm2。近一半的受试者患有骨质疏松症（44.1%，95%CI：33.8%，54.8%）和骨质疏松症（47.3%，95%CI：36.9%，57.9%）。I 型胶原 C 端肽（CTX）的循环水平与腰椎（r=-0.26，p=0.01）和股骨颈 BMD （r=-0.25，p=0.02）显著相关。
居住在养老院的泰国老年女性中，有超过三分之一的人维生素 D 不足。几乎所有养老院居民都有骨质疏松症和/或骨质疏松症。
