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Wnt 信号在成肌中的作用。

Wnt signaling in myogenesis.

机构信息

Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

出版信息

Trends Cell Biol. 2012 Nov;22(11):602-9. doi: 10.1016/j.tcb.2012.07.008. Epub 2012 Aug 31.

DOI:10.1016/j.tcb.2012.07.008
PMID:22944199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3479319/
Abstract

The formation of skeletal muscle is a tightly regulated process that is critically modulated by Wnt signaling. Myogenesis is dependent on the precise and dynamic integration of multiple Wnt signals allowing self-renewal and progression of muscle precursors in the myogenic lineage. Dysregulation of Wnt signaling can lead to severe developmental defects and perturbation of muscle homeostasis. Recent work has revealed novel roles for the non-canonical planar cell polarity (PCP) and AKT/mTOR pathways in mediating the effects of Wnt on skeletal muscle. In this review, we discuss the role of Wnt signaling in myogenesis and in regulating the homeostasis of adult muscle.

摘要

成骨过程是一个受到严格调控的过程，Wnt 信号的调控至关重要。成肌作用依赖于多种 Wnt 信号的精确和动态整合，允许肌肉前体细胞在成肌谱系中自我更新和进展。Wnt 信号的失调可导致严重的发育缺陷和肌肉内稳态的破坏。最近的工作揭示了非经典的平面细胞极性（PCP）和 AKT/mTOR 途径在介导 Wnt 对骨骼肌肉的影响方面的新作用。在这篇综述中，我们讨论了 Wnt 信号在成肌作用和调节成年肌肉内稳态中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ca8/3479319/cf5b8e2b53ff/nihms399478f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ca8/3479319/920fa94a8f53/nihms399478f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ca8/3479319/093f4a2ce8c3/nihms399478f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ca8/3479319/cf5b8e2b53ff/nihms399478f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ca8/3479319/920fa94a8f53/nihms399478f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ca8/3479319/093f4a2ce8c3/nihms399478f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ca8/3479319/cf5b8e2b53ff/nihms399478f3.jpg

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