Nazneen Farzana, Bai Fengwei
Department of Cell and Molecular Biology, Center for Molecular and Cellular Biosciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA.
Vaccines (Basel). 2020 Dec 9;8(4):748. doi: 10.3390/vaccines8040748.
Osteopontin (OPN), a multifunctional protein encoded by the gene in humans, plays important roles in a variety of physiological conditions, such as biomineralization, bone remodeling and immune functions. OPN also has significant roles in the pathogenesis of autoimmune, allergy and inflammatory diseases, as well as bacterial, fungal and viral infections. West Nile virus (WNV), a mosquito-transmitted flavivirus, is the leading agent for viral encephalitis in North America. Recent progress has been made in understanding both the biological functions of OPN and the pathogenesis of WNV. In this review article, we have summarized the current understanding of the biology of OPN and its vital roles in the pathogenesis of WNV encephalitis.
骨桥蛋白（OPN）是一种由人类基因编码的多功能蛋白质，在多种生理状况中发挥重要作用，如生物矿化、骨重塑和免疫功能。OPN在自身免疫性、过敏性和炎性疾病以及细菌、真菌和病毒感染的发病机制中也具有重要作用。西尼罗河病毒（WNV）是一种通过蚊子传播的黄病毒，是北美病毒性脑炎的主要病原体。在了解OPN的生物学功能和WNV的发病机制方面均取得了最新进展。在这篇综述文章中，我们总结了目前对OPN生物学的认识及其在WNV脑炎发病机制中的重要作用。
