Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125 001, India.
Int J Biol Macromol. 2012 Dec;51(5):1086-90. doi: 10.1016/j.ijbiomac.2012.08.023. Epub 2012 Aug 27.
Carboxymethylation of xanthan gum was carried out by reacting xanthan gum with monochloroacetic acid in alkaline condition. FTIR spectroscopy confirmed the formation of carboxymethyl xanthan. DSC and XRD study revealed the crystalline nature of carboxymethyl xanthan. SEM images showed that carboxymethyl xanthan particles are globular in shape and smaller in size. Viscosity measurements also showed that the carboxymethyl xanthan is less viscous as compared to xanthan gum. Diclofenac sodium matrix tablets prepared using carboxymethyl xanthan revealed faster release of drug as compared with xanthan gum matrix.
黄原胶的羧甲基化反应是在碱性条件下，用一氯乙酸对黄原胶进行反应。傅里叶变换红外光谱（FTIR）证实了羧甲基黄原胶的形成。差示扫描量热法（DSC）和 X 射线衍射（XRD）研究表明，羧甲基黄原胶具有结晶性。扫描电子显微镜（SEM）图像显示，羧甲基黄原胶颗粒呈球形，且粒径较小。黏度测量也表明，与黄原胶相比，羧甲基黄原胶的黏度较低。使用羧甲基黄原胶制备的双氯芬酸钠基质片显示出比黄原胶基质更快的药物释放。
