Department of Exercise Physiology, Faculty of Physical Education & Sport Science, University of Mazandaran, Babolsar, Iran.
Endocrine. 2013 Jun;43(3):564-70. doi: 10.1007/s12020-012-9786-9. Epub 2012 Sep 5.
Inflammation plays an important role in the genesis and progression of diabetes. The purpose of this study was to investigate the effect of resistance training on serum levels of some inflammatory markers associated with diabetes mellitus. Twenty-four male Wistar rats (290 ± 19 g) were randomly divided into three groups: non-diabetic control (non-DC), diabetic control (DC), and diabetic trained (DT). Animals in DT group were subjected to a resistance training program with the use of a ladder (3 days/week, for 4 weeks). Body weight, serum high sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, tumor necrosis factor (TNF)-α, fasting glucose, and insulin were measured. Four weeks of resistance training decreased serum levels of TNF-α, hs-CRP, and IL-6 in diabetic rats when compared with DC animals. We conclude that resistance training with appropriate intensity, duration, and recovery between exercise bouts has marked anti-inflammatory effects on diabetic rats. This may be an efficient strategy to protect against some diabetic complications.
炎症在糖尿病的发生和发展中起着重要作用。本研究旨在探讨抗阻训练对与糖尿病相关的一些炎症标志物血清水平的影响。将 24 只雄性 Wistar 大鼠（290±19g）随机分为三组：非糖尿病对照组（non-DC）、糖尿病对照组（DC）和糖尿病训练组（DT）。DT 组动物进行了使用梯子的抗阻训练计划（每周 3 天，共 4 周）。测量了体重、血清高敏 C 反应蛋白（hs-CRP）、白细胞介素（IL）-6、肿瘤坏死因子（TNF）-α、空腹血糖和胰岛素。与 DC 动物相比，4 周的抗阻训练降低了糖尿病大鼠的血清 TNF-α、hs-CRP 和 IL-6 水平。我们得出结论，适当强度、持续时间和运动间隙恢复的抗阻训练对糖尿病大鼠具有明显的抗炎作用。这可能是预防某些糖尿病并发症的有效策略。
