Louisville Metabolic and Atherosclerosis Research Center, Louisville, KY, USA.
Eur J Clin Nutr. 2013 Jan;67(1):2-7. doi: 10.1038/ejcn.2012.121. Epub 2012 Sep 5.
BACKGROUND/OBJECTIVES: Elevated oxidized low-density lipoprotein (OxLDL) may promote inflammation, and is associated with increased risk of atherosclerotic coronary heart disease and worsening complications of diabetes mellitus. The primary objective of this study was to evaluate the efficacy of chitin-glucan (CG), alone and in combination with a potentially anti-inflammatory olive oil (OO) extract, for reducing OxLDL in subjects with borderline to high LDL cholesterol (LDL-C) levels.
SUBJECTS/METHODS: This 6-week, randomized, double-blind, placebo-controlled study of a novel, insoluble fiber derived from the Aspergillus niger mycelium, CG, evaluated 130 subjects free of diabetes mellitus with fasting LDL-C 3.37-4.92 mmol/l and glucose ≤ 6.94 mmol/l. Participants were randomly assigned to receive CG (4.5 g/day; n=33), CG (1.5 g/day; n=32), CG (1.5 g/day) plus OO extract (135 mg/day; n=30), or matching placebo (n=35).
Administration of 4.5 g/day CG for 6 weeks significantly reduced OxLDL compared with placebo (P=0.035). At the end of study, CG was associated with lower LDL-C levels relative to placebo, although this difference was statistically significant only for the CG 1.5 g/day group (P=0.019). CG did not significantly affect high-density lipoprotein cholesterol, triglycerides, glucose, insulin or F2-isoprostane levels. Adverse events did not substantively differ between treatments and placebo.
In this 6-week study, CG (4.5 g/day) reduced OxLDL, an effect that might affect the risk for atherosclerosis.
背景/目的：氧化型低密度脂蛋白（OxLDL）升高可能会促进炎症，并与动脉粥样硬化性冠心病风险增加和糖尿病并发症恶化相关。本研究的主要目的是评估壳聚糖-葡聚糖（CG）单独使用以及与具有潜在抗炎作用的橄榄油（OO）提取物联合使用，降低 LDL 胆固醇（LDL-C）水平处于边缘至较高水平的受试者的 OxLDL 的疗效。
受试者/方法：这项为期 6 周的、随机的、双盲、安慰剂对照研究评估了一种新型、不溶于水的纤维，它来源于黑曲霉菌丝体，CG，共纳入了 130 名无糖尿病、空腹 LDL-C 为 3.37-4.92mmol/L 且血糖≤6.94mmol/L 的受试者。参与者被随机分配接受 CG（4.5g/天；n=33）、CG（1.5g/天；n=32）、CG（1.5g/天）加 OO 提取物（135mg/天；n=30）或匹配的安慰剂（n=35）。
6 周内给予 4.5g/天 CG 可显著降低 OxLDL，与安慰剂相比差异有统计学意义（P=0.035）。在研究结束时，与安慰剂相比，CG 与 LDL-C 水平降低相关，但仅 CG 1.5g/天组的差异具有统计学意义（P=0.019）。CG 对高密度脂蛋白胆固醇、甘油三酯、血糖、胰岛素或 F2-异前列烷水平无显著影响。治疗与安慰剂之间的不良事件没有实质性差异。
在这项为期 6 周的研究中，CG（4.5g/天）降低了 OxLDL，这种作用可能会影响动脉粥样硬化的风险。
