Department of Neurology, Vanderbilt University Medical Center, 1161 21st Avenue South, A-0118 Medical Center North, Nashville, TN 37232, USA.
Curr Neurol Neurosci Rep. 2012 Dec;12(6):695-702. doi: 10.1007/s11910-012-0312-5.
In this review, we first discuss trends and issues in measuring cognitive changes in PD, including recent efforts to define the diagnostic classification of "PD Mild Cognitive Impairment" (PD-MCI). After reviewing some limitations associated with this diagnosis, we discuss how measures derived from the neurocognitive sciences offer better precision in detecting early cognitive changes in PD. To support this idea, we highlight 2 influential lines of current investigation that are unveiling novel insights about specific cognitive processes that are vulnerable early in PD and of critical importance to clinicians involved in treating PD: action control and reward learning and decision making. We conclude by highlighting some extant issues and unresolved questions for future investigations.
在这篇综述中,我们首先讨论了在 PD 中测量认知变化的趋势和问题,包括最近为定义“PD 轻度认知障碍”(PD-MCI)的诊断分类所做的努力。在回顾了与该诊断相关的一些局限性之后,我们讨论了如何从神经认知科学中获取的方法可以更准确地检测 PD 中的早期认知变化。为了支持这一观点,我们重点介绍了当前正在进行的两项有影响力的研究,它们揭示了有关 PD 早期易损的特定认知过程的新见解,这些过程对治疗 PD 的临床医生至关重要:行为控制以及奖励学习和决策。最后,我们强调了未来研究中存在的一些问题和未解决的问题。