College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China.
J Zhejiang Univ Sci B. 2012 Sep;13(9):676-94. doi: 10.1631/jzus.B1100339.
In order to better understand biatrial conduction, investigate various conduction pathways, and compare the differences between isotropic and anisotropic conductions in human atria, we present a simulation study of biatrial conduction with known/assumed conduction pathways using a recently developed human atrial model. In addition to known pathways: (1) Bachmann's bundle (BB), (2) limbus of fossa ovalis (LFO), and (3) coronary sinus (CS), we also hypothesize that there exist two fast conduction bundles that connect the crista terminalis (CT), LFO, and CS. Our simulation demonstrates that use of these fast conduction bundles results in a conduction pattern consistent with experimental data. The comparison of isotropic and anisotropoic conductions in the BB case showed that the atrial working muscles had small effect on conduction time and conduction speed, although the conductivities assigned in anisotropic conduction were two to four times higher than the isotropic conduction. In conclusion, we suggest that the hypothesized intercaval bundles play a significant role in the biatrial conduction and that myofiber orientation has larger effects on the conduction system than the atrial working muscles. This study presents readers with new insights into human atrial conduction.
为了更好地理解双房传导，研究各种传导途径，并比较人类心房各向同性和各向异性传导之间的差异，我们使用最近开发的人类心房模型，对具有已知/假定传导途径的双房传导进行了模拟研究。除了已知的途径：（1）Bachmann 束（BB）、（2）卵圆窝嵴缘（LFO）和（3）冠状窦（CS），我们还假设存在两个连接心耳终嵴（CT）、LFO 和 CS 的快速传导束。我们的模拟表明，使用这些快速传导束会产生与实验数据一致的传导模式。在 BB 情况下，各向同性和各向异性传导的比较表明，心房工作肌对传导时间和传导速度的影响较小，尽管各向异性传导中分配的电导率是各向同性传导的两到四倍。总之，我们认为假设的腔静脉束在双房传导中起着重要作用，肌纤维方向对传导系统的影响大于心房工作肌。本研究为读者提供了对人类心房传导的新见解。
