TFAP2B 影响能量限制下饮食脂肪对减肥的作用。
TFAP2B influences the effect of dietary fat on weight loss under energy restriction.
机构信息
Institute of Preventive Medicine, Copenhagen University Hospital, Frederiksberg, Denmark.
出版信息
PLoS One. 2012;7(8):e43212. doi: 10.1371/journal.pone.0043212. Epub 2012 Aug 27.
BACKGROUND
Numerous gene loci are related to single measures of body weight and shape. We investigated if 55 SNPs previously associated with BMI or waist measures, modify the effects of fat intake on weight loss and waist reduction under energy restriction.
METHODS AND FINDINGS
Randomized controlled trial of 771 obese adults. (
REGISTRATION
ISRCTN25867281.) One SNP was selected for replication in another weight loss intervention study of 934 obese adults. The original trial was a 10-week 600 kcal/d energy-deficient diet with energy percentage from fat (fat%) in range of 20-25 or 40-45. The replication study used an 8-weeks diet of 880 kcal/d and 20 fat%; change in fat% intake was used for estimation of interaction effects. The main outcomes were intervention weight loss and waist reduction. In the trial, mean change in fat% intake was -12/+4 in the low/high-fat groups. In the replication study, it was -23/-12 among those reducing fat% more/less than the median. TFAP2B-rs987237 genotype AA was associated with 1.0 kg (95% CI, 0.4; 1.6) greater weight loss on the low-fat, and GG genotype with 2.6 kg (1.1; 4.1) greater weight loss on the high-fat (interaction p-value; p = 0.00007). The replication study showed a similar (non-significant) interaction pattern. Waist reduction results generally were similar. Study-strengths include (i) the discovery study randomised trial design combined with the replication opportunity (ii) the strict dietary intake control in both studies (iii) the large sample sizes of both studies. Limitations are (i) the low minor allele frequency of the TFAP2B polymorphism, making it hard to investigate non-additive genetic effects (ii) the different interventions preventing identical replication-discovery study designs (iii) some missing data for non-completers and dietary intake. No adverse effects/outcomes or side-effects were observed.
CONCLUSIONS
Under energy restriction, TFAP2B may modify the effect of dietary fat intake on weight loss and waist reduction.
背景
许多基因座与体重和体型的单一指标有关。我们研究了之前与 BMI 或腰围相关的 55 个 SNP 是否会改变脂肪摄入对能量限制下体重减轻和腰围减少的影响。
方法和发现
对 771 名肥胖成年人进行随机对照试验。（
注册
ISRCTN25867281。）选择一个 SNP 进行另一个 934 名肥胖成年人减肥干预研究的复制。原始试验是为期 10 周的 600 卡路里/天能量不足饮食，脂肪能量百分比（脂肪%）在 20-25 或 40-45 之间。复制研究使用 8 周的 880 卡路里/天和 20%脂肪的饮食；改变脂肪%的摄入量用于估计交互作用的影响。主要结果是干预体重减轻和腰围减少。在试验中，低/高脂肪组的脂肪%摄入量平均变化为-12/+4。在复制研究中，在那些减少脂肪%的人中间，-23/-12 高于中位数。TFAP2B-rs987237 基因型 AA 与低脂饮食中体重减轻 1.0 公斤（95%CI，0.4；1.6）相关，GG 基因型与高脂饮食中体重减轻 2.6 公斤（1.1；4.1）相关（交互 p 值；p=0.00007）。复制研究显示出类似的（非显著）相互作用模式。腰围减少的结果一般相似。研究的优势包括（i）发现研究的随机试验设计结合了复制机会（ii）两项研究中严格的饮食摄入控制（iii）两项研究的样本量都很大。局限性包括（i）TFAP2B 多态性的次要等位基因频率较低，难以研究非加性遗传效应（ii）不同的干预措施阻止了相同的复制-发现研究设计（iii）一些非完成者和饮食摄入的数据缺失。没有观察到不良影响/结果或副作用。
结论
在能量限制下，TFAP2B 可能会改变脂肪摄入对体重减轻和腰围减少的影响。
Zotero 插件