Qualitative and quantitative comparison of gallbladder proteins from patients with and without cholesterol gallstones.

Amino acid analysis and protein electrophoretic techniques were used to determine whether qualitative and quantitative gallbladder protein abnormalities exist in patients with cholesterol gallstones in Inner Mongolia. Gallbladder bile osmotic pressure measurement was determined and correlations were sought between the protein concentration and osmotic pressure of gallbladder bile. Protein concentrations and bile osmolality were higher in patients with cholesterol gallstones than in controls without biliary tract disease. A correlation between the protein concentration and osmotic pressure was found in gallbladder patients but not in controls (patients: r = 0.83, P less than 0.05; controls: r = 0.74, P less than 0.1).