从灵芝子实体中分离得到的一种新型中性多糖的结构特征。
Structure characterization of a novel neutral polysaccharide isolated from Ganoderma lucidum fruiting bodies.
机构信息
State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, PR China.
出版信息
Food Chem. 2012 Dec 1;135(3):1097-103. doi: 10.1016/j.foodchem.2012.05.071. Epub 2012 May 24.
Ganoderma lucidum (G. lucidum) is a mushroom which has been used for health promotion for a long time in China. In the present work a neutral hetero-polysaccharide, named FYGL-1, was isolated from FYGL which was reported previously capable of antihyperglycemia in vivo for further detailed chemical structure investigation. The results of monosaccharide composition and GPC analysis indicated that FYGL-1 consisted of galactose, rhamnose and glucose in mole ratio of 1.00:1.15:3.22 with a molecular weight of 78kDa. The detailed structure of FYGL-1 was characterized by periodate oxidation, Smith degradation, methylation analysis, along with FT-IR, GC, GC-MS, 1D (1)H and (13)C NMR and 2D NMR (HSQC, COSY, NOESY and TOCSY). Based on the analysis of the results, the structure of the repeating unit of FYGL-1 was established as:
灵芝（Ganoderma lucidum）是一种在中国长期用于促进健康的蘑菇。在本工作中，从 FYGL 中分离出一种中性杂多糖 FYGL-1，FYGL 先前被报道具有体内降血糖作用，用于进一步进行详细的化学结构研究。单糖组成和 GPC 分析结果表明，FYGL-1 由半乳糖、鼠李糖和葡萄糖组成，摩尔比为 1.00:1.15:3.22，分子量为 78kDa。FYGL-1 的详细结构通过高碘酸氧化、Smith 降解、甲基化分析以及 FT-IR、GC、GC-MS、1D（1）H 和（13）C NMR 和 2D NMR（HSQC、COSY、NOESY 和 TOCSY）进行了表征。基于分析结果，确定 FYGL-1 的重复单元结构为：
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