文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

在幽门螺杆菌和寄生虫感染的背景下，结核感染的免疫反应。

The immune response to tuberculosis infection in the setting of Helicobacter pylori and helminth infections.

机构信息

Stanford University School of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford, CA, USA.

出版信息

Epidemiol Infect. 2013 Jun;141(6):1232-43. doi: 10.1017/S0950268812001823. Epub 2012 Sep 7.

DOI:10.1017/S0950268812001823
PMID:22954328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3785541/
Abstract

We screened 176 healthy, adult (aged 18-55 years) US refugees from tuberculosis (TB)-endemic countries to evaluate whether cytokine responses to latent TB infection (LTBI) are modified in the setting of concurrent H. pylori and helminth infection. As measured by the Quantiferon-TB GOLD interferon-γ release assay, a total 38 (22%) subjects had LTBI, of which 28 (74%) also were H. pylori seropositive and/or helminth infected. Relative to ten subjects with LTBI only, 16 subjects with concurrent H. pylori infection had significantly elevated levels of IFN-γ, and nine subjects with both H. pylori and helminth infection had significantly elevated levels of IFN-γ, IL-2, IL-13, and IL-5. H. pylori is associated with enhanced IFN-γ responses to TB, even in the setting of concurrent helminth infection. Efficacy of TB vaccines may vary with the co-existence of these three infections in the developing world.

摘要

我们筛查了 176 名来自结核病（TB）流行国家的健康成年（18-55 岁）美国难民，以评估在同时存在 H. pylori 和寄生虫感染的情况下，针对潜伏性结核感染（LTBI）的细胞因子反应是否会发生变化。通过 Quantiferon-TB GOLD 干扰素-γ释放检测，共有 38 名（22%）受试者存在 LTBI，其中 28 名（74%）受试者同时 H. pylori 血清阳性和/或寄生虫感染。与仅存在 LTBI 的 10 名受试者相比，16 名同时存在 H. pylori 感染的受试者的 IFN-γ 水平显著升高，9 名同时存在 H. pylori 和寄生虫感染的受试者的 IFN-γ、IL-2、IL-13 和 IL-5 水平也显著升高。即使在同时存在寄生虫感染的情况下，H. pylori 也与对 TB 的增强 IFN-γ 反应有关。在发展中国家，TB 疫苗的疗效可能会因这三种感染同时存在而有所不同。

相似文献

[1]
The immune response to tuberculosis infection in the setting of Helicobacter pylori and helminth infections.

Epidemiol Infect. 2012-9-7

[2]
Factors associated with tuberculosis infection, and with anti-mycobacterial immune responses, among five year olds BCG-immunised at birth in Entebbe, Uganda.

Vaccine. 2015-2-4

[3]
Infection with Helicobacter pylori is associated with protection against tuberculosis.

PLoS One. 2010-1-20

[4]
[Immune response Th1/Th2 to Helicobacter pylori and Helminths in co-infected patients].

Rev Chil Pediatr. 2020-6

[5]
HIV patients with latent tuberculosis living in a low-endemic country do not develop active disease during a 2 year follow-up; a Norwegian prospective multicenter study.

BMC Infect Dis. 2014-12-17

[6]
Potential Role for Mycobacterium tuberculosis Specific IL-2 and IFN-γ Responses in Discriminating between Latent Infection and Active Disease after Long-Term Stimulation.

PLoS One. 2016-12-29

[7]
Detection of interleukin-2 is not useful for distinguishing between latent and active tuberculosis in clinical practice: a prospective cohort study.

Clin Microbiol Infect. 2016-9-16

[8]
Improving T-cell assays for diagnosis of latent TB infection: Confirmation of the potential role of testing Interleukin-2 release in Iranian patients.

Allergol Immunopathol (Madr). 2016

[9]
Identification of mycobacterial bacterioferritin B for immune screening of tuberculosis and latent tuberculosis infection.

Tuberculosis (Edinb). 2017-12

[10]
PpiA antigen specific immune response is a potential biomarker for latent tuberculosis infection.

Tuberculosis (Edinb). 2015-12

引用本文的文献

[1]
Gut microbiota and tuberculosis infection: interaction and therapeutic potential.

Gut Microbes. 2025-12

[2]
At Early Rheumatoid Arthritis Stage, the Infectious Spectrum Is Driven by Non-Familial Factors and Anti-CCP Immunization.

J Clin Med. 2024-5-9

[3]
The Interplay between and Human Microbiome.

Clin Pract. 2024-1-24

[4]
Host microbiome in tuberculosis: disease, treatment, and immunity perspectives.

Front Microbiol. 2023-9-22

[5]
Impact of the gut-lung axis on tuberculosis susceptibility and progression.

Front Microbiol. 2023-7-6

[6]
Effect of Helicobacter pylori and Helminth Coinfection on the Immune Response to Mycobacterium tuberculosis.

Curr Microbiol. 2021-9

[7]
The gut microbiome in tuberculosis susceptibility and treatment response: guilty or not guilty?

Cell Mol Life Sci. 2019-11-15

[8]
Good Agreement between an Interferon Gamma Release Assay and Tuberculin Skin Tests in Testing for Latent Tuberculosis Infection among HIV-Infected Patients in Indonesia.

J Korean Med Sci. 2019-10-21

[9]
Prokaryotic horizontal gene transfer within the human holobiont: ecological-evolutionary inferences, implications and possibilities.

Microbiome. 2018-9-17

[10]
New Players in Immunity to Tuberculosis: The Host Microbiome, Lung Epithelium, and Innate Immune Cells.

Front Immunol. 2018-4-10

本文引用的文献

[1]
Understanding latent tuberculosis: the key to improved diagnostic and novel treatment strategies.

Drug Discov Today. 2011-12-20

[2]
Estimating the burden of tuberculosis among foreign-born persons acquired prior to entering the U.S., 2005-2009.

PLoS One. 2011-11-29

[3]
BCG vaccination induces different cytokine profiles following infant BCG vaccination in the UK and Malawi.

J Infect Dis. 2011-10-1

[4]
Diversity and dialogue in immunity to helminths.

Nat Rev Immunol. 2011-6

[5]
Clinical application and limitations of interferon-gamma release assays for the diagnosis of latent tuberculosis infection.

Clin Infect Dis. 2011-4-15

[6]
The impact of mucosal infections on acquisition and progression of tuberculosis.

Mucosal Immunol. 2011-3-16

[7]
IL-17 and Th17 cells in tuberculosis.

Cytokine Growth Factor Rev. 2010-11-12

[8]
The immune system and the gut microbiota: friends or foes?

Nat Rev Immunol. 2010-10

[9]
Understanding latent tuberculosis: a moving target.

J Immunol. 2010-7-1

[10]
Infection with Helicobacter pylori is associated with protection against tuberculosis.

PLoS One. 2010-1-20

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索