Neuroscience Graduate Program, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.
Mol Cell Neurosci. 2013 Jul;55:87-94. doi: 10.1016/j.mcn.2012.08.002. Epub 2012 Aug 11.
Despite years of intensive research, the understanding of Parkinson's disease (PD) is still rudimentary. Genetic causes of rare familial cases have offered venues of investigation, and interestingly, have strengthened the case for a mitochondrial dysfunction in the pathogenesis of PD. Mouse models, where these and other mitochondrial-related genes are affected are helping not only in understanding PD, but also in providing a powerful tool to test therapeutics. In this review, we will discuss the different characteristics of these mouse models. This article is part of a Special Issue entitled 'Mitochondrial function and dysfunction in neurodegeneration'.
尽管经过多年的深入研究，人们对帕金森病 (PD) 的认识仍然很基础。罕见家族性病例的遗传原因提供了研究的途径，有趣的是，这也加强了线粒体功能障碍在 PD 发病机制中的作用。受这些和其他与线粒体相关基因影响的小鼠模型不仅有助于了解 PD，而且为测试治疗方法提供了有力工具。在这篇综述中，我们将讨论这些小鼠模型的不同特征。本文是特刊“神经退行性疾病中的线粒体功能和功能障碍”的一部分。
