Omodaka Kazuko, Takada Naoko, Yamaguchi Takuhiro, Takahashi Hidetoshi, Araie Makoto, Nakazawa Toru
Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan.
Jpn J Ophthalmol. 2015 Jul;59(4):223-9. doi: 10.1007/s10384-015-0379-z. Epub 2015 Apr 11.
To investigate the influence of the optic disc type on the overall and regional correlation between structure and function in open angle glaucoma (OAG).
We divided 144 eyes of 144 patients with OAG into four groups according to Nicolela et al.'s classification of optic disc type: focal ischemic (FI), myopic glaucomatous (MY), senile sclerotic (SS), and generalized enlargement (GE). We measured the circumpapillary retinal nerve fiber layer thickness (cpRNFLT) with the 3D OCT-2000 and the mean deviation (MD) with the Humphrey Field Analyzer in each group and determined the influence of the disc type on these parameters with the Spearman rank correlation.
We found that cpRNFLT and MD were significantly correlated in the MY (r = 0.61, P < 0.001), GE (r = 0.62, P < 0.001), and SS groups (r = 0.52, P = 0.002), but not in the FI group (r = 0.25, P = 0.130). The region of the optic disc with the highest correlation coefficient between structure and function differed according to the disc type.
The correlation between cpRNFLT and MD varied according to the optic disc morphology in OAG. This suggests that different disc types have characteristic regional variations in the correlation between structure and function. The disc type should therefore be considered in investigations of the correlation between structure and function in glaucoma.
探讨视盘类型对开角型青光眼（OAG）结构与功能整体及局部相关性的影响。
根据Nicolela等人对视盘类型的分类，将144例OAG患者的144只眼分为四组：局灶性缺血型（FI）、近视性青光眼型（MY）、老年性硬化型（SS）和普遍性扩大型（GE）。我们使用3D OCT - 2000测量每组的视乳头周围视网膜神经纤维层厚度（cpRNFLT），并使用Humphrey视野分析仪测量平均偏差（MD），通过Spearman等级相关性分析视盘类型对这些参数的影响。
我们发现，cpRNFLT与MD在MY组（r = 0.61，P < 0.001）、GE组（r = 0.62，P < 0.001）和SS组（r = 0.52，P = 0.002）中显著相关，但在FI组中不相关（r = 0.25，P = 0.130）。视盘结构与功能之间相关系数最高的区域因视盘类型而异。
在OAG中，cpRNFLT与MD之间的相关性因视盘形态而异。这表明不同的视盘类型在结构与功能的相关性上具有特征性的局部差异。因此，在青光眼结构与功能相关性的研究中应考虑视盘类型。
