Department of Biochemistry and Biophysics, UCSF Center for Systems and Synthetic Biology, University of California, San Francisco, San Francisco, CA 94158, USA.
Science. 2012 Sep 7;337(6099):1186-9. doi: 10.1126/science.1223539.
Cells have developed ways to sense and control the size of their organelles. Size-sensing mechanisms range from direct measurements provided by dedicated reporters to indirect functional readouts, and they are used to modify organelle size under both normal and stress conditions. Organelle size can also be controlled in the absence of an identifiable size sensor. Studies on flagella have dissected principles of size sensing and control, and it will be exciting to see how these principles apply to other organelles.
细胞已经发展出感知和控制细胞器大小的方法。大小感知机制范围从专用报告器提供的直接测量到间接功能读数,并且它们用于在正常和应激条件下修改细胞器大小。在没有可识别的大小传感器的情况下,细胞器大小也可以控制。关于鞭毛的研究已经剖析了大小感知和控制的原则,看到这些原则如何应用于其他细胞器将是令人兴奋的。