Department of General and Biological Psychology, University of Marburg, Gutenbergstrasse 18, 35032 Marburg, Germany.
Soc Cogn Affect Neurosci. 2013 Dec;8(8):918-27. doi: 10.1093/scan/nss094. Epub 2012 Sep 5.
Parkinson's disease (PD) has been related to impaired processing of emotional speech intonation (emotional prosody). One distinctive feature of idiopathic PD is motor symptom asymmetry, with striatal dysfunction being strongest in the hemisphere contralateral to the most affected body side. It is still unclear whether this asymmetry may affect vocal emotion perception. Here, we tested 22 PD patients (10 with predominantly left-sided [LPD] and 12 with predominantly right-sided motor symptoms) and 22 healthy controls in an event-related potential study. Sentences conveying different emotional intonations were presented in lexical and pseudo-speech versions. Task varied between an explicit and an implicit instruction. Of specific interest was emotional salience detection from prosody, reflected in the P200 component. We predicted that patients with predominantly right-striatal dysfunction (LPD) would exhibit P200 alterations. Our results support this assumption. LPD patients showed enhanced P200 amplitudes, and specific deficits were observed for disgust prosody, explicit anger processing and implicit processing of happy prosody. Lexical speech was predominantly affected while the processing of pseudo-speech was largely intact. P200 amplitude in patients correlated significantly with left motor scores and asymmetry indices. The data suggest that emotional salience detection from prosody is affected by asymmetric neuronal degeneration in PD.
帕金森病（PD）与情绪言语语调（情感韵律）处理受损有关。特发性 PD 的一个显著特征是运动症状的不对称性，与受影响身体侧相对的大脑半球的纹状体功能障碍最强。目前尚不清楚这种不对称性是否会影响声音的情感感知。在这里，我们在事件相关电位研究中测试了 22 名 PD 患者（10 名主要左侧[LPD]和 12 名主要右侧运动症状）和 22 名健康对照者。传达不同情感语调的句子以词汇和拟声形式呈现。任务在明确和隐含指令之间变化。特别感兴趣的是从韵律中检测情感显著性，这反映在 P200 成分中。我们预测主要右侧纹状体功能障碍（LPD）的患者会出现 P200 改变。我们的结果支持这一假设。LPD 患者的 P200 振幅增强，并且在厌恶韵律、明确愤怒处理和隐含快乐韵律处理方面观察到特定的缺陷。词汇语音受到主要影响，而拟声语音的处理基本完整。患者的 P200 振幅与左侧运动评分和不对称指数显著相关。数据表明，情感韵律的显著性检测受到 PD 中不对称性神经元退化的影响。
