Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, People's Republic of China.
Int J Nanomedicine. 2012;7:4715-25. doi: 10.2147/IJN.S34902. Epub 2012 Aug 28.
Recently, nanoparticles have been demonstrated to have tremendous merit in terms of improving the treatment specificity and thermal ablation effect on tumors. However, the potential toxicity and long-term side effects caused by the introduced nanoparticles and by expelling them out of the body following surgery remain a significant challenge. Here, we propose for the first time to directly adopt magnesium nanoparticles as the heating enhancer in laser thermal ablation to avoid these problems by making full use of the perfect biodegradable properties of this specific material.
To better understand the new nano "green" hyperthermia modality, we evaluated the effects of magnesium nanoparticles on the temperature transients inside the human body subject to laser interstitial heating. Further, we experimentally investigated the heating enhancement effects of magnesium nanoparticles on a group of biological samples: oil, egg white, egg yolk, in vitro pig tissues, and the in vivo hind leg of rabbit when subjected to laser irradiation.
Both the theoretical simulations and experimental measurements demonstrated that the target tissues injected with magnesium nanoparticles reached much higher temperatures than tissues without magnesium nanoparticles. This revealed the enhancing behavior of the new nanohyperthermia method.
Given the unique features of magnesium nanoparticles--their complete biological safety and ability to enhance heating--which most other advanced metal nanoparticles do not possess, the use of magnesium nanoparticles in hyperthermia therapy offers an important "green" nanomedicine modality for treating tumors. This method has the potential to be used in clinics in the near future.
最近，纳米颗粒在提高肿瘤治疗的特异性和热消融效果方面显示出巨大的优势。然而，引入的纳米颗粒的潜在毒性和手术后排出体外的长期副作用仍然是一个重大挑战。在这里，我们首次提出直接将镁纳米颗粒用作激光热消融的加热增强剂，通过充分利用这种特殊材料的完全可生物降解特性来避免这些问题。
为了更好地理解新的纳米“绿色”热疗模式，我们评估了镁纳米颗粒对激光间质加热时人体内部温度瞬变的影响。此外，我们还实验研究了镁纳米颗粒对一组生物样本的加热增强效果：油、蛋清、蛋黄、体外猪组织以及兔的活体后腿在激光照射下的效果。
理论模拟和实验测量都表明，注入镁纳米颗粒的靶组织达到了比没有镁纳米颗粒的组织更高的温度。这揭示了新纳米热疗方法的增强行为。
鉴于镁纳米颗粒的独特特性——完全的生物安全性和增强加热的能力——这是大多数其他先进金属纳米颗粒所不具备的，将镁纳米颗粒用于热疗提供了一种治疗肿瘤的重要“绿色”纳米医学模式。这种方法有望在不久的将来在临床上应用。
