Rawat Digvijay Singh, Sonkhya Divij, Sonkhya Nishi, Gupta Shubha
Department of E.N.T, S.M.S. Medical College and Hospital, Jaipur, Rajasthan 302004, India.
Case Rep Otolaryngol. 2012;2012:537381. doi: 10.1155/2012/537381. Epub 2012 Aug 22.
Parapharyngeal space tumors are rare and constitute only 0.5-1.0% of head and neck tumors. Minor salivary gland tumor is still rare in parapharyngeal space. We are reporting a case of pleomorphic adenoma of minor salivary gland of parapharyngeal space. A 42-year-old female presented with a history of mass in the oropharynx for 3 years. She presented with "hot potato voice" and dysphagia. CECT and MRI were done, showing large parapharyngeal space tumor. FNAC was suspicious for tumor of nerve cell origin. Tumor was excised using "paramedian mandibulotomy with mandibular swing approach". Histopathological examination was inconclusive, suggesting possibility of extraskeletal myxoid chondrosarcoma, solitary fibrous tumor, neurogenic tumor. On immunohistochemistry, tumor was positive for cytokeratin, EMA (dim), S-100, and P 63 and negative for SMA thus proving the case as myoepithelial cell-rich pleomorphic adenoma.
咽旁间隙肿瘤较为罕见,仅占头颈部肿瘤的0.5 - 1.0%。小唾液腺肿瘤在咽旁间隙仍属罕见。我们报告一例咽旁间隙小唾液腺多形性腺瘤病例。一名42岁女性,有口咽部肿物3年病史。她出现“热土豆声”和吞咽困难。进行了增强CT(CECT)和磁共振成像(MRI)检查,显示咽旁间隙有巨大肿瘤。细针穿刺抽吸活检(FNAC)怀疑为神经细胞起源的肿瘤。采用“经下颌骨正中切开下颌骨摆动入路”切除肿瘤。组织病理学检查结果不明确,提示可能为骨外黏液样软骨肉瘤、孤立性纤维瘤、神经源性肿瘤。免疫组化显示,肿瘤细胞角蛋白、上皮膜抗原(弱阳性)、S - 100和P63呈阳性,平滑肌肌动蛋白(SMA)呈阴性,从而证实该病例为富含肌上皮细胞的多形性腺瘤。