Matsuda H, Watanabe N, Kiso Y, Hirota S, Ushio H, Kannan Y, Azuma M, Koyama H, Kitamura Y
Department of Veterinary Surgery, College of Agriculture, University of Osaka Prefecture, Japan.
J Immunol. 1990 Jan 1;144(1):259-62.
Genetically mast cell-deficient WBB6F1-W/Wv mice showed an apparent defect in manifestation of the resistance against larval Haemaphysalis longicornis ticks, but their serum IgE levels increased more than 100-fold after the second tick infestation. Immune sera obtained from the WBB6F1-W/Wv mice were adoptively transferred to the other WBB6F1-W/Wv mice which had received intracutaneous injections of WBB6F1-+/+ mouse-derived cultured mast cells. Because the resistance against ticks was detectable only when both mast cells and IgE antibodies were available, immediate hypersensitivity reaction appeared to have a physiologic role in the manifestation of the resistance against H. longicornis ticks.
基因性肥大细胞缺陷的WBB6F1-W/Wv小鼠在抵抗长角血蜱幼虫的表现上存在明显缺陷，但在第二次蜱虫感染后其血清IgE水平增加了100多倍。从WBB6F1-W/Wv小鼠获得的免疫血清被过继转移到其他接受了皮内注射WBB6F1-+/+小鼠来源的培养肥大细胞的WBB6F1-W/Wv小鼠体内。由于只有当肥大细胞和IgE抗体都存在时才能检测到对蜱虫的抵抗力，因此速发型超敏反应似乎在抵抗长角血蜱的表现中具有生理作用。
