汉族人群中促氧化剂或抗氧化酶（髓过氧化物酶、SOD2 和 CAT）及基因的多态性与前列腺癌风险的相关性。
The association between polymorphisms in prooxidant or antioxidant enzymes (myeloperoxidase, SOD2, and CAT) and genes and prostate cancer risk in the Chinese population of Han nationality.
机构信息
Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.
出版信息
Clin Genitourin Cancer. 2012 Dec;10(4):251-5. doi: 10.1016/j.clgc.2012.08.001. Epub 2012 Sep 5.
BACKGROUND
Oxidative stress was associated with prostate cancer (PCa). The expressions of prooxidant or antioxidant enzymes (myeloperoxidase [MPO], superoxide dismutase (SOD2), and catalase (CAT)) have been proved to be related to gene polymorphisms. Our study aimed to evaluate the association between genetic polymorphisms and the risk of PCa.
METHODS
Genotyping was carried out by genotyping system (MassARRAY iPLEX; Sequenom Inc, San Diego, CA) in 1388 patients with PCa and 1008 cancer-free controls in the Chinese population.
RESULTS
One SNP of SOD2 (rs5746136; P < .050, odds ratios (OR), 0.8806) was significant. Another SNP was shown to have limited association with the risk of PCa (rs554518; P = .09443) in all SNPs of CAT. In other SNPs, no significant difference was shown between genotype distributions in the patients with PCa and the control group.
CONCLUSIONS
Our data showed that rs5746136 of SOD2 was associated with susceptibility to PCa in the Chinese population of Han nationality. The possible association between rs8082134 of CAT and PCa risk needs further verification.
背景
氧化应激与前列腺癌（PCa）有关。已证明促氧化剂或抗氧化酶（髓过氧化物酶[MPO]、超氧化物歧化酶 2（SOD2）和过氧化氢酶（CAT））的表达与基因多态性有关。我们的研究旨在评估基因多态性与 PCa 风险之间的关联。
方法
通过基因分型系统（MassARRAY iPLEX；Sequenom Inc，圣地亚哥，CA）对中国人群中的 1388 例 PCa 患者和 1008 例无癌对照进行基因分型。
结果
SOD2 的一个 SNP（rs5746136；P<.050，比值比[OR]，0.8806）具有统计学意义。CAT 的所有 SNP 中，另一个 SNP 与 PCa 的风险也显示出有限的关联（rs554518；P=.09443）。在其他 SNP 中，PCa 患者和对照组的基因型分布之间没有显示出显著差异。
结论
我们的数据表明，SOD2 的 rs5746136 与汉族中国人群中 PCa 的易感性有关。CAT 的 rs8082134 与 PCa 风险之间的可能关联需要进一步验证。
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