Işikli Ali, Kubat-Üzüm Ayşe, Satman İlhan, Matur Zeliha, Öge A Emre, Küçükali Cem İsmail, Tüzün Erdem, Erden Sacide, Özkök Elif
Department of Neuroscience, Aziz Sancar Institute for Experimental Medicine, İstanbul University, İstanbul, Turkey.
Department of Internal Medicine, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey.
Noro Psikiyatr Ars. 2018 Apr 20;55(3):276-279. doi: 10.29399/npa.23027. eCollection 2018 Sep.
Diabetes mellitus (DM) affects peripheral nerves inducing diabetic polyneuropathy (DPN). Mitochondrial dysfunction and oxidative stress are potential causes of DPN.
Nerve conduction studies were performed in 20 type 2 DM patients (11 with DPN) and 15 healthy controls. Perception threshold values of cold, warm and vibration were measured by quantitative sensory testing. Variants of a superoxide dismutase 2 (SOD2) gene single nucleotide polymorphism (SNP) (rs5746136) were determined by polymerase chain reaction (PCR) and following NexteraXT DNA Library.
DPN patients showed significantly increased threshold values. DM patients without DPN and healthy controls showed comparable values. TT variant of the SOD2 SNP was more prevalent in DM and DPN patients. DM patients with the TT variant displayed increased perception threshold values.
Quantitative sensory testing is not superior to standard nerve conduction studies in DPN. Carriers of SOD2 SNP manifested increased sensory threshold levels which is important in further corroborating the link between oxidative stress and DPN.
糖尿病（DM）会影响周围神经，引发糖尿病性多发性神经病变（DPN）。线粒体功能障碍和氧化应激是DPN的潜在病因。
对20例2型糖尿病患者（11例患有DPN）和15名健康对照者进行神经传导研究。通过定量感觉测试测量冷、温觉和振动觉的感知阈值。通过聚合酶链反应（PCR）及随后的NexteraXT DNA文库测定超氧化物歧化酶2（SOD2）基因单核苷酸多态性（SNP）（rs5746136）的变体。
DPN患者的阈值显著升高。无DPN的糖尿病患者和健康对照者的阈值相当。SOD2 SNP的TT变体在糖尿病患者和DPN患者中更为普遍。携带TT变体的糖尿病患者的感知阈值升高。
在DPN中，定量感觉测试并不优于标准神经传导研究。SOD2 SNP携带者的感觉阈值水平升高，这对于进一步证实氧化应激与DPN之间的联系具有重要意义。
