Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Trends Immunol. 2012 Dec;33(12):598-606. doi: 10.1016/j.it.2012.07.006. Epub 2012 Sep 5.
Innate immune and differentiated T cells produce signature cytokines in response to cytokine stimulation. Optimal production requires stimulation by an NF-κB inducer, most commonly an interleukin (IL)-1 family member, and a STAT activator. Usually, there is linkage between the IL-1 family member, the activated STAT and the cytokines produced: IFNγ producers respond to the IL-1 family member, IL-18 and IL-12, a STAT4 activator; IL-13 producers respond to IL-33 (although for ILC2 cells this may be replaced by IL-25) and STAT5 activators; for cells producing IL-17A or IL-22, the combination is IL-1 and a STAT3 inducer. Cytokine-induced cytokine production may have broad significance in orchestrating innate responses to distinct infectious agents and in maintaining inflammatory responses after elimination of the inciting antigen.
先天免疫和分化的 T 细胞在受到细胞因子刺激时会产生特征性细胞因子。最佳的产生需要 NF-κB 诱导剂的刺激，最常见的是白细胞介素 (IL)-1 家族成员和 STAT 激活剂。通常情况下，IL-1 家族成员、激活的 STAT 和产生的细胞因子之间存在联系：IFNγ 产生细胞对 IL-1 家族成员、IL-18 和 IL-12（STAT4 激活剂）作出反应；IL-13 产生细胞对 IL-33（尽管对于 ILC2 细胞，这可能被 IL-25 取代）和 STAT5 激活剂作出反应；对于产生 IL-17A 或 IL-22 的细胞，组合是 IL-1 和 STAT3 诱导剂。细胞因子诱导的细胞因子产生可能在协调对不同感染因子的先天反应以及在消除激发抗原后维持炎症反应方面具有广泛意义。
