Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Nat Immunol. 2012 Jan 22;13(3):229-36. doi: 10.1038/ni.2208.
Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously unknown members of the lymphoid lineage. Nuocytes required interleukin 7 (IL-7), IL-33 and Notch signaling for development in vitro. Pro-T cell progenitors at double-negative stage 1 (DN1) and DN2 maintained nuocyte potential in vitro, although the thymus was not essential for nuocyte development. Notably, the transcription factor RORα was critical for the development of nuocytes and their role in the expulsion of parasitic worms.
类初始细胞在先天 2 型免疫中起关键作用，并促进哮喘反应恶化。在此，我们发现类初始细胞起源于骨髓，由普通淋巴祖细胞分化而来，这表明它们是淋巴谱系中独特的、先前未知的成员。类初始细胞的体外发育需要白细胞介素 7（IL-7）、IL-33 和 Notch 信号。双阴性阶段 1（DN1）和 DN2 的前 T 细胞祖细胞在体外维持类初始细胞的潜能，尽管胸腺对于类初始细胞的发育并非必需。值得注意的是，转录因子 RORα 对于类初始细胞的发育及其在驱除寄生虫中的作用至关重要。
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