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十二指肠转流/胆胰分流术与 Roux-en-Y 胃旁路术相比的优势和并发症。

Benefits and complications of the duodenal switch/biliopancreatic diversion compared to the Roux-en-Y gastric bypass.

机构信息

Department of Surgery, University of Minnesota, Minneapolis, MN 55444, USA.

出版信息

Surgery. 2012 Oct;152(4):758-65; discussion 765-7. doi: 10.1016/j.surg.2012.07.023. Epub 2012 Sep 6.

Abstract

BACKGROUND

Despite providing superb excess weight loss and increased resolution of comorbid diseases, such as type 2 diabetes mellitus, compared to other bariatric procedures, the duodenal switch/ biliopancreatic diversion (DS/BD) has not gained widespread acceptance among patients and physicians. In this study, we investigated outcomes, symptoms and complications among postsurgical DS patients compared to RYGB patients.

METHODS

We used propensity scores to retrospectively match patients who underwent DS/BD between 2005 and 2010 to comparable Roux-en-Y gastric bypass (RYGB) patients. We then reviewed patient charts, and surveyed patients using the University of Minnesota Bariatric Surgery Outcomes Survey tool to track outcomes, comorbid illnesses and complications.

RESULTS

One hundred ninety consecutive patients underwent primary DS/BD between 2005 and 2010 at the University of Minnesota Medical Center. There were 178 patients available for follow-up (93.7%) who were matched to 139 RYGB patients. Type 2 diabetes, hypertension, and hyperlipidemia all significantly improved in each group. Improvements were significantly higher in the DS/BD group. Percent total weight loss was not different between groups. Loose stools and bloating symptoms were more frequently reported among DS/BD patients. With the exception of increased emergency department visits among DS/BD patients (P < .01), overall complication rates were not significantly different between DS/BD and RYGB. There was no difference in mortality rates between the groups.

CONCLUSION

The DS/BD is a robust procedure that engenders both superior weight loss and improvement of major comorbidities. Complication and adverse event rates are similar to those of RYGB.

摘要

背景

与其他减重手术相比,十二指肠转位/胆胰分流术(DS/BD)在提供出色的超重减轻和改善合并症方面,如 2 型糖尿病,并未在患者和医生中获得广泛认可。在这项研究中,我们调查了与 RYGB 患者相比,接受 DS/BD 手术后患者的结果、症状和并发症。

方法

我们使用倾向评分回顾性地将 2005 年至 2010 年间接受 DS/BD 的患者与可比的 Roux-en-Y 胃旁路术(RYGB)患者相匹配。然后,我们查阅了患者的病历,并使用明尼苏达大学减重手术结果调查工具对患者进行了调查,以跟踪结果、合并症和并发症。

结果

在明尼苏达大学医学中心,190 例连续患者在 2005 年至 2010 年间接受了原发性 DS/BD。有 178 例患者可进行随访(93.7%),并与 139 例 RYGB 患者相匹配。两组患者的 2 型糖尿病、高血压和高脂血症均显著改善。DS/BD 组的改善更为显著。两组之间的总体重减轻百分比没有差异。DS/BD 患者更频繁地报告腹泻和腹胀症状。除了 DS/BD 患者急诊就诊次数增加(P<.01)外,DS/BD 和 RYGB 之间的总体并发症发生率没有显著差异。两组的死亡率没有差异。

结论

DS/BD 是一种强大的手术,既能提供出色的减重效果,又能改善主要合并症。并发症和不良事件发生率与 RYGB 相似。

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