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单纯十二指肠转流术或联合袖状胃切除术对大鼠体重及脂代谢的影响。

Effects of duodenal switch alone or in combination with sleeve gastrectomy on body weight and lipid metabolism in rats.

机构信息

1] Department of Clinical Medicine, University of Bergen, Bergen, Norway [2] Department of Clinical Science, University of Bergen, Bergen, Norway.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

出版信息

Nutr Diabetes. 2014 Jun 30;4(6):e124. doi: 10.1038/nutd.2014.22.

DOI:10.1038/nutd.2014.22
PMID:24979153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4079930/
Abstract

BACKGROUND

A combined procedure of sleeve gastrectomy and duodenal switch (SG+DS) has been applied to the treatment of super obesity. The aim of the present study was to test whether duodenal switch alone (DS) leads to similar weight loss and changes in lipid metabolism as SG+DS.

METHODS

Male Sprague-Dawley rats underwent sham surgery (Sham, N=7), duodenal switch alone (DS, N=5) or sleeve gastrectomy followed by duodenal switch (SG+DS, N=5). Body weight, feed and water intakes, and ambulatory activity were recorded 2 months post surgery. Tissue and faecal lipids, faecal bile acids, plasma cytokines and lipid metabolism-related gene expression in adipose tissue and liver were analysed.

RESULTS

Daily energy intake, relative feed uptake, ambulatory activity and body weight reduction were similar between DS and SG+DS rats. The hepatic triacylglycerol content was higher and faecal secretion of triacylglycerol was lower after SG+DS compared to DS (P<0.05). Faecal bile acid secretion was higher in SG+DS than in DS rats (P<0.05) despite similar hepatic CYP7A1mRNA level. Plasma levels of proinflammatory cytokines interleukin (IL)-1b, IL-2, IL-4, IL-5, IL-6, IL-12, granulocyte-macrophage colony stimulating factor and tumour necrosis factor alpha were higher in SG+DS than in DS rats (P<0.05).

CONCLUSIONS

Although DS and SG+DS had similar efficacy in terms of body weight loss, SG+DS resulted in a poorer regulation of lipid metabolism than DS.

摘要

背景

袖状胃切除术联合十二指肠转流术（SG+DS）已应用于治疗超级肥胖症。本研究旨在检验单纯十二指肠转流术（DS）是否能达到与 SG+DS 相似的减肥效果和脂代谢变化。

方法

雄性 Sprague-Dawley 大鼠接受假手术（Sham，N=7）、单纯十二指肠转流术（DS，N=5）或袖状胃切除术后十二指肠转流术（SG+DS，N=5）。术后 2 个月记录体重、饲料和水的摄入以及活动量。分析组织和粪便脂质、粪便胆汁酸、血浆细胞因子和脂肪组织及肝脏中与脂代谢相关的基因表达。

结果

DS 组和 SG+DS 组大鼠的每日能量摄入、相对饲料摄取量、活动量和体重减轻均相似。与 DS 相比，SG+DS 后肝三酰甘油含量升高，粪便三酰甘油分泌减少（P<0.05）。尽管肝 CYP7A1mRNA 水平相似，但 SG+DS 大鼠的粪便胆汁酸分泌高于 DS 组（P<0.05）。SG+DS 组大鼠的促炎细胞因子白细胞介素（IL）-1b、IL-2、IL-4、IL-5、IL-6、IL-12、粒细胞-巨噬细胞集落刺激因子和肿瘤坏死因子-α的血浆水平高于 DS 组（P<0.05）。

结论

尽管 DS 和 SG+DS 在体重减轻方面疗效相似，但 SG+DS 导致脂代谢调节较 DS 更差。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb8b/4079930/718fde4d6b1f/nutd201422f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb8b/4079930/718fde4d6b1f/nutd201422f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb8b/4079930/718fde4d6b1f/nutd201422f1.jpg

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