Department of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India.
Dis Markers. 2012;33(4):207-13. doi: 10.3233/DMA-2012-0926.
Obesity is considered as a strong risk factor of inflammatory periodontal tissue destruction. The purpose of this study is to determine presence of progranulin (PGRN) and high sensitivity C reactive protein (hs CRP) levels in serum and gingival crevicular fluid (GCF) in obese subjects with chronic periodontitis and to find an association, if any.
40 subjects (20 males and 20 females) were selected based on their clinical parameters into four groups (10 subjects in each group): group 1 (healthy non obese), group 2 (healthy obese), group 3 (non obese with chronic periodontitis) and group 4 (obese with chronic periodontitis). Serum and GCF PGRN levels were estimated by enzyme linked immunosorbant assay (ELISA) and hs CRP levels were estimated by immunoturbidimetry method.
The mean PGRN and hs CRP concentration both in serum and GCF were highest for group 4 followed by group 3, group 2 and least in Group 1.
PGRN and hs CRP may be novel biomarkers of the chronic inflammatory response in obesity and chronic periodontitis.
肥胖被认为是导致炎症性牙周组织破坏的一个强危险因素。本研究的目的是确定肥胖的慢性牙周炎患者血清和龈沟液（GCF）中颗粒体蛋白（PGRN）和高敏 C 反应蛋白（hs CRP）的水平，并探讨它们之间是否存在关联。
根据临床参数，将 40 名受试者（20 名男性和 20 名女性）分为 4 组（每组 10 名）：第 1 组（健康非肥胖者）、第 2 组（健康肥胖者）、第 3 组（非肥胖慢性牙周炎患者）和第 4 组（肥胖慢性牙周炎患者）。通过酶联免疫吸附试验（ELISA）测定血清和 GCF 中的 PGRN 水平，通过免疫比浊法测定 hs CRP 水平。
血清和 GCF 中的 PGRN 和 hs CRP 浓度均以第 4 组最高，其次是第 3 组、第 2 组，第 1 组最低。
PGRN 和 hs CRP 可能是肥胖和慢性牙周炎慢性炎症反应的新型生物标志物。
