Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, V5Z 4S6, Canada.
Genome Res. 2012 Nov;22(11):2262-9. doi: 10.1101/gr.140665.112. Epub 2012 Sep 7.
Biologists possess the detailed knowledge critical for extracting biological insight from genome-wide data resources, and yet they are increasingly faced with nontrivial computational analysis challenges posed by genome-scale methodologies. To lower this computational barrier, particularly in the early data exploration phases, we have developed an interactive pattern discovery and visualization approach, Spark, designed with epigenomic data in mind. Here we demonstrate Spark's ability to reveal both known and novel epigenetic signatures, including a previously unappreciated binding association between the YY1 transcription factor and the corepressor CTBP2 in human embryonic stem cells.
生物学家拥有从全基因组数据资源中提取生物学见解所需的详细知识，但他们越来越多地面临基因组规模方法带来的非平凡计算分析挑战。为了降低这个计算障碍，特别是在早期的数据探索阶段，我们开发了一种交互式模式发现和可视化方法 Spark，它是专门针对表观基因组数据设计的。在这里，我们展示了 Spark 揭示已知和新颖的表观遗传特征的能力，包括在人类胚胎干细胞中以前未被重视的 YY1 转录因子和核心抑制因子 CTBP2 之间的结合关联。
