School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India.
Nanomedicine. 2013 Apr;9(3):439-48. doi: 10.1016/j.nano.2012.08.001. Epub 2012 Sep 5.
Cerium oxide nanoparticles (nanoceria) have recently received attention from the scientific community due to their unique free radicals (specially superoxide radical and hydrogen peroxide) scavenging property in biological system, both in vitro and in vivo. It is suggested that free radicals play an important role in the pathogenesis of endometriosis. In this study we have shown that nanoceria mitigate the endometrial lesions induced in mice model by decreasing oxidative stress and inhibiting angiogenesis. Moreover, nanoceria were also observed to protect endometriosis-related adverse effects on the oocytes, which is critical for successful pregnancy. Summarizing, nanoceria have shown promising efficacy against endometriosis related pathogenesis.
Free radicals have been implemented in the pathogenesis of endometriosis. In a murine model the authors demonstrated successful treatment of endometriosis with nanoceria, and protection of endometriosis-related adverse effects on the oocytes, paving the way to potential clinical translational applications in the future.
氧化铈纳米粒子（纳米氧化铈）由于其在生物体系中独特的清除自由基（特别是超氧自由基和过氧化氢）的特性，无论是在体外还是体内，最近都引起了科学界的关注。有研究表明，自由基在子宫内膜异位症的发病机制中起重要作用。本研究表明，纳米氧化铈通过降低氧化应激和抑制血管生成来减轻小鼠模型中的子宫内膜损伤。此外，还观察到纳米氧化铈可以保护与子宫内膜异位症相关的对卵子的不良影响，这对于成功妊娠至关重要。总之，纳米氧化铈在对抗与子宫内膜异位症相关的发病机制方面显示出有前景的疗效。
自由基已被应用于子宫内膜异位症的发病机制中。作者在鼠模型中证明了纳米氧化铈可成功治疗子宫内膜异位症，并保护与子宫内膜异位症相关的对卵子的不良影响，为未来潜在的临床转化应用铺平了道路。
