Deparment of Gastroenterology, Antalya Training and Research Hospital, Antalya, Turkey.
BMC Gastroenterol. 2012 Sep 10;12:122. doi: 10.1186/1471-230X-12-122.
Blastocystosis is a frequent bowel disease. We planned to to evaluate the prevalence of Blastocystis spp. in patients who applied to the same internal medicine-gastroenterology clinic with or without gastrointestinal complaints to reveal the association of this parasite with diagnosed IBS and IBD.
A total of 2334 patients with gastrointestinal symptoms composed the study group, which included 335 patients with diagnosed inflammatory bowel disease and 877 with irritable bowel syndrome. Patients without any gastrointestinal symptoms or disease (n = 192) composed the control group. Parasite presence was investigated by applying native-Lugol and formol ethyl acetate concentration to stool specimens, and trichrome staining method in suspicious cases.
Blastocystis spp. was detected in 134 patients (5.74%) in the study group and 6 (3.12%) in the control group (p = 0.128). In the study group, Blastocystis spp. was detected at frequencies of 8.7% in ulcerative colitis (24/276), 6.78% in Crohn's disease (4/59), 5.82% in irritable bowel syndrome (51/877), and 4.9% in the remaining patients with gastrointestinal symptoms (55/1122). Blastocystis spp. was detected at a statistically significant ratio in the inflammatory bowel disease (odds ratio [OR] = 2.824; 95% confidence interval [CI]: 1.149-6.944; p = 0.019) and ulcerative colitis (OR = 2.952; 95% CI: 1.183-7.367; p = 0.016) patients within this group compared to controls. There were no statistically significant differences between the control group and Crohn's disease or irritable bowel syndrome patients in terms Blastocystis spp. frequency (p = 0.251, p = 0.133).
Blastocystosis was more frequent in patients with inflammatory bowel disease, especially those with ulcerative colitis. Although symptomatic irritable bowel syndrome and Crohn's disease patients had higher rates of Blastocystis spp. infection, the differences were not significant when compared to controls.
芽囊原虫病是一种常见的肠道疾病。我们计划评估患有或不患有胃肠道症状的患者中芽囊原虫的流行率，以揭示该寄生虫与诊断为 IBS 和 IBD 的相关性。
共有 2334 名有胃肠道症状的患者组成了研究组，其中包括 335 名患有炎症性肠病的患者和 877 名患有肠易激综合征的患者。无任何胃肠道症状或疾病的患者（n=192）组成对照组。通过应用天然卢戈氏液和福尔马林乙基乙酸酯浓缩液对粪便标本进行检查，并在可疑病例中应用三色染色法来检测寄生虫的存在。
在研究组中，134 名患者（5.74%）和 6 名对照组患者（3.12%）中检测到芽囊原虫（p=0.128）。在研究组中，溃疡性结肠炎患者中芽囊原虫的检出率为 8.7%（24/276），克罗恩病患者为 6.78%（4/59），肠易激综合征患者为 5.82%（51/877），其余有胃肠道症状的患者为 4.9%（55/1122）。在该组中，与对照组相比，芽囊原虫在炎症性肠病（比值比[OR] = 2.824；95%置信区间[CI]：1.149-6.944；p=0.019）和溃疡性结肠炎（OR=2.952；95%CI：1.183-7.367；p=0.016）患者中以统计学显著比例检出。在对照组与克罗恩病或肠易激综合征患者之间，芽囊原虫的检出率无统计学显著差异（p=0.251，p=0.133）。
芽囊原虫病在炎症性肠病患者中更为常见，尤其是溃疡性结肠炎患者。尽管有症状的肠易激综合征和克罗恩病患者感染芽囊原虫的比例较高，但与对照组相比，差异无统计学意义。
